Mutation familiale de l’ARN de transfert de la sélénocystéine (tRNA[Ser]Sec) : évaluation clinique et hormonale chez 2 patients
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.137
Abstract: Introduction La synthese des selenoproteines necessite l’insertion d’une seleneocysteine par un complexe multi-proteique comprenant le tRNA[Ser]Sec. Une mutation du gene TRU-TCA1-1, codant pour le tRNA[Ser]Sec a ete recemment decrite, responsable d’une diminution de l’expression des… read more here.
Keywords: trna ser; chez; ser sec; mutation ... See more keywords
A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium.
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DOI: 10.1093/nar/gkad482
Abstract: The selenocysteine (Sec) tRNA (tRNA[Ser]Sec) governs Sec insertion into selenoproteins by the recoding of a UGA codon, typically used as a stop codon. A homozygous point mutation (C65G) in the human tRNA[Ser]Sec acceptor arm has… read more here.
Keywords: trna ser; uga recoding; ser sec; mutation ... See more keywords
Upregulation of tRNA-Ser-AGA-2-1 Promotes Malignant Behavior in Normal Bronchial Cells
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DOI: 10.3389/fmolb.2022.809985
Abstract: Serine tRNAs (tRNASer) are frequently overexpressed in tumors and associated with poor prognosis and increased risk of recurrence in breast cancer. Impairment of tRNA biogenesis and abundance also impacts proteome homeostasis, and activates protein quality… read more here.
Keywords: aga; ser aga; trnaser; trna ser ... See more keywords