An unknown essential function of tRNA splicing endonuclease is linked to the integrated stress response and intron debranching.
Sign Up to like & getrecommendations! Published in 2023 at "Genetics"
DOI: 10.1093/genetics/iyad044
Abstract: tRNA splicing endonuclease (TSEN) has a well-characterized role in tRNA splicing, but also other functions. For yeast TSEN, these other functions include degradation of a subset of mRNAs that encode mitochondrial proteins and an unknown… read more here.
Keywords: function; splicing endonuclease; intron debranching; essential function ... See more keywords
Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage.
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DOI: 10.1093/nar/gkaa438
Abstract: The splicing of tRNA introns is a critical step in pre-tRNA maturation. In archaea and eukaryotes, tRNA intron removal is catalyzed by the tRNA splicing endonuclease (TSEN) complex. Eukaryotic TSEN is comprised of four core… read more here.
Keywords: splicing endonuclease; pre trna; trna splicing; trna ... See more keywords
Eukaryotic tRNA splicing – one goal, two strategies, many players
Sign Up to like & getrecommendations! Published in 2022 at "Biological Chemistry"
DOI: 10.1515/hsz-2021-0402
Abstract: Abstract Transfer RNAs (tRNAs) are transcribed as precursor molecules that undergo several maturation steps before becoming functional for protein synthesis. One such processing mechanism is the enzyme-catalysed splicing of intron-containing pre-tRNAs. Eukaryotic tRNA splicing is… read more here.
Keywords: goal two; splicing one; eukaryotic trna; trna splicing ... See more keywords