New molecular insights into the tyrosyl-tRNA synthase inhibitors: CoMFA, CoMSIA analyses and molecular docking studies
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DOI: 10.1038/s41598-017-10618-1
Abstract: Drug resistance caused by excessive and indiscriminate antibiotic usage has become a serious public health problem. The need of finding new antibacterial drugs is more urgent than ever before. Tyrosyl-tRNA synthase was proved to be… read more here.
Keywords: synthase inhibitors; comsia; trna synthase; tyrosyl trna ... See more keywords
A tRNA synthase in metabolic control
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DOI: 10.1126/science.367.6474.158-n
Abstract: Signal Transduction Leucyl-tRNA synthetase 1 (LARS1), which covalently couples leucine to its cognate transfer RNAs (tRNAs), appears to have broader roles in the control of leucine metabolism. The enzyme also serves as a leucine sensor… read more here.
Keywords: trna synthase; metabolic control; synthase metabolic; science ... See more keywords