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   Articles with "trna synthetase" as a keyword



Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors

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recommendations! Published in 2019 at "Molecular Diversity"

DOI: 10.1007/s11030-019-10011-2

Abstract: In the current study, we used an integrated approach combining bioinformatics, rational drug design, one-pot synthesis, and biological experiments in vitro for the potential discovery of novel tryptophanyl-tRNA synthetase (TrpRS) inhibitors. Atom economic and diastereoselective… read more here.

Keywords: indenoquinoxaline; tryptophanyl trna; spirooxindole indenoquinoxaline; novel tryptophanyl ... See more keywords
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Corrigendum to "A continuous tyrosyl-tRNA synthetase assay that regenerates the tRNA substrate" [Anal. Biochem. 486 (2015) 86-95].

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recommendations! Published in 2017 at "Analytical biochemistry"

DOI: 10.1016/j.ab.2016.11.002

Abstract: The authors regret that in Figure 3 panels B and D, Figure 5 panels B and D, and Figure 6 panel D, kobs (i.e., v0/[Enzyme]) is plotted on the y-axis rather than v0, as indicated… read more here.

Keywords: synthetase assay; trna synthetase; corrigendum continuous; continuous tyrosyl ... See more keywords
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Establishment of Inhibitor Screening and Validation System for Tryptophanyl tRNA Synthetase Using Surface Plasmon Resonance.

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recommendations! Published in 2021 at "Analytical biochemistry"

DOI: 10.1016/j.ab.2021.114183

Abstract: With the increase in throughput and sensitivity, biophysical technology has become a major component of the early drug discovery phase. Surface plasmon resonance technology (SPR) is one of the most widely used biophysical technologies. It… read more here.

Keywords: tryptophanyl trna; trna synthetase; surface plasmon; validation system ... See more keywords
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Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.01.045

Abstract: Protein translation is highly activated in cancer tissues through oncogenic mutations and amplifications, and this can support survival and aberrant proliferation. Therefore, blocking translation could be a promising way to block cancer progression. The process… read more here.

Keywords: death; prolyl trna; gcn2 atf4; atf4 pathway ... See more keywords
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Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.09.008

Abstract: Leucyl-tRNA synthetase (LRS) plays major roles in providing leucine-tRNA and activating mechanistic target of rapamycin complex 1 (mTORC1) through intracellular leucine sensing. mTORC1 activated by amino acids affects the influence on physiology functions including cell… read more here.

Keywords: microscopy; leucine sensing; leucyl trna; trna synthetase ... See more keywords
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Glycyl-tRNA synthetase from Nanoarchaeum equitans: The first crystal structure of archaeal GlyRS and analysis of its tRNA glycylation.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.01.142

Abstract: This study reports the X-ray crystallographic structure of the glycyl-tRNA synthetase (GlyRS) of Nanoarchaeum equitans - a hyperthermophilic archaeal species. This is the first archaeal GlyRS crystal structure elucidated. The GlyRS comprises an N-terminal catalytic… read more here.

Keywords: glycyl trna; trna synthetase; structure; nanoarchaeum equitans ... See more keywords
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An archaeal aminoacyl-tRNA synthetase complex for improved substrate quality control.

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recommendations! Published in 2018 at "Biochimie"

DOI: 10.1016/j.biochi.2017.12.006

Abstract: Aminoacyl-tRNA synthetases (aaRSs) decode genetic information by coupling tRNAs with cognate amino acids. In the archaeon Methanothermobacter thermautotrophicus arginyl- and seryl-tRNA synthetase (ArgRS and SerRS, respectively) form a complex which enhances serylation and facilitates tRNASer… read more here.

Keywords: trnaarg; serrs; aminoacyl trna; trna synthetase ... See more keywords
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Novel partial loss-of-function variants in the tyrosyl-tRNA synthetase 1 (YARS1) gene involved in multisystem disease.

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recommendations! Published in 2021 at "European journal of medical genetics"

DOI: 10.1016/j.ejmg.2021.104294

Abstract: Cytoplasmic aminoacyl-tRNA synthetases (ARSs) are emerging as a cause of numerous rare inherited diseases. Recently, biallelic variants in tyrosyl-tRNA synthetase 1 (YARS1) have been described in ten patients of three families with multi-systemic disease (failure… read more here.

Keywords: variants tyrosyl; synthetase yars1; yars1; trna synthetase ... See more keywords
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On the Mechanism and Origin of Isoleucyl-tRNA Synthetase Editing against Norvaline.

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recommendations! Published in 2019 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2019.01.029

Abstract: Aminoacyl-tRNA synthetases (aaRSs), the enzymes responsible for coupling tRNAs to their cognate amino acids, minimize translational errors by intrinsic hydrolytic editing. Here, we compared norvaline (Nva), a linear amino acid not coded for protein synthesis,… read more here.

Keywords: editing nva; isoleucyl trna; trna synthetase; transfer editing ... See more keywords
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Symmetric Assembly of a Decameric Subcomplex in Human Multi-tRNA Synthetase Complex Via Interactions between Glutathione Transferase-Homology Domains and Aspartyl-tRNA Synthetase.

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recommendations! Published in 2019 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2019.08.013

Abstract: Aminoacyl-tRNA synthetases (AARSs) ligate amino acids to their cognate tRNAs during protein synthesis. In humans, eight AARSs and three non-enzymatic AARS-interacting multifunctional proteins (AIMP1-3), which are involved in various biological processes, form a multi-tRNA synthetase… read more here.

Keywords: drs; gst; trna synthetase; synthetase complex ... See more keywords

In vivo characterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL

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recommendations! Published in 2017 at "Neurobiology of Disease"

DOI: 10.1016/j.nbd.2016.10.008

Abstract: BACKGROUND The recently diagnosed leukodystrophy Hypomyelination with Brain stem and Spinal cord involvement and Leg spasticity (HBSL) is caused by mutations of the cytoplasmic aspartyl-tRNA synthetase geneDARS. The physiological role of DARS in translation is… read more here.

Keywords: aspartyl trna; trna synthetase; leukodystrophy; mice ... See more keywords