Evolution and variation in amide aminoacyl‐tRNA synthesis
Sign Up to like & getrecommendations! Published in 2024 at "IUBMB Life"
DOI: 10.1002/iub.2811
Abstract: The amide proteogenic amino acids, asparagine and glutamine, are two of the twenty amino acids used in translation by all known life. The aminoacyl‐tRNA synthetases for asparagine and glutamine, asparaginyl‐tRNA synthetase and glutaminyl tRNA synthetase,… read more here.
Keywords: trna; trna synthetase; synthesis; aminoacyl trna ... See more keywords
Potential Piperolactam A Isolated From Piper betle as Natural Inhibitors of Brucella Species Aminoacyl‐tRNA Synthetase for Livestock Infections: In Silico Approach
Sign Up to like & getrecommendations! Published in 2024 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.70042
Abstract: ABSTRACT Brucellosis is an important global zoonosis caused by the bacterium Brucella sp. Brucellosis causes abortions, reproductive failure and reduced milk production, resulting in significant economic losses. Brucella species are reported to be resistant to… read more here.
Keywords: piperolactam; trna synthetase; brucella species; aminoacyl trna ... See more keywords
Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Diversity"
DOI: 10.1007/s11030-019-10011-2
Abstract: In the current study, we used an integrated approach combining bioinformatics, rational drug design, one-pot synthesis, and biological experiments in vitro for the potential discovery of novel tryptophanyl-tRNA synthetase (TrpRS) inhibitors. Atom economic and diastereoselective… read more here.
Keywords: indenoquinoxaline; tryptophanyl trna; spirooxindole indenoquinoxaline; novel tryptophanyl ... See more keywords
Corrigendum to "A continuous tyrosyl-tRNA synthetase assay that regenerates the tRNA substrate" [Anal. Biochem. 486 (2015) 86-95].
Sign Up to like & getrecommendations! Published in 2017 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2016.11.002
Abstract: The authors regret that in Figure 3 panels B and D, Figure 5 panels B and D, and Figure 6 panel D, kobs (i.e., v0/[Enzyme]) is plotted on the y-axis rather than v0, as indicated… read more here.
Keywords: synthetase assay; trna synthetase; corrigendum continuous; continuous tyrosyl ... See more keywords
Establishment of Inhibitor Screening and Validation System for Tryptophanyl tRNA Synthetase Using Surface Plasmon Resonance.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114183
Abstract: With the increase in throughput and sensitivity, biophysical technology has become a major component of the early drug discovery phase. Surface plasmon resonance technology (SPR) is one of the most widely used biophysical technologies. It… read more here.
Keywords: tryptophanyl trna; trna synthetase; surface plasmon; validation system ... See more keywords
Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.045
Abstract: Protein translation is highly activated in cancer tissues through oncogenic mutations and amplifications, and this can support survival and aberrant proliferation. Therefore, blocking translation could be a promising way to block cancer progression. The process… read more here.
Keywords: death; prolyl trna; gcn2 atf4; atf4 pathway ... See more keywords
Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.008
Abstract: Leucyl-tRNA synthetase (LRS) plays major roles in providing leucine-tRNA and activating mechanistic target of rapamycin complex 1 (mTORC1) through intracellular leucine sensing. mTORC1 activated by amino acids affects the influence on physiology functions including cell… read more here.
Keywords: microscopy; leucine sensing; leucyl trna; trna synthetase ... See more keywords
Glycyl-tRNA synthetase from Nanoarchaeum equitans: The first crystal structure of archaeal GlyRS and analysis of its tRNA glycylation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.01.142
Abstract: This study reports the X-ray crystallographic structure of the glycyl-tRNA synthetase (GlyRS) of Nanoarchaeum equitans - a hyperthermophilic archaeal species. This is the first archaeal GlyRS crystal structure elucidated. The GlyRS comprises an N-terminal catalytic… read more here.
Keywords: glycyl trna; trna synthetase; structure; nanoarchaeum equitans ... See more keywords
An archaeal aminoacyl-tRNA synthetase complex for improved substrate quality control.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2017.12.006
Abstract: Aminoacyl-tRNA synthetases (aaRSs) decode genetic information by coupling tRNAs with cognate amino acids. In the archaeon Methanothermobacter thermautotrophicus arginyl- and seryl-tRNA synthetase (ArgRS and SerRS, respectively) form a complex which enhances serylation and facilitates tRNASer… read more here.
Keywords: trnaarg; serrs; aminoacyl trna; trna synthetase ... See more keywords
Novel partial loss-of-function variants in the tyrosyl-tRNA synthetase 1 (YARS1) gene involved in multisystem disease.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2021.104294
Abstract: Cytoplasmic aminoacyl-tRNA synthetases (ARSs) are emerging as a cause of numerous rare inherited diseases. Recently, biallelic variants in tyrosyl-tRNA synthetase 1 (YARS1) have been described in ten patients of three families with multi-systemic disease (failure… read more here.
Keywords: variants tyrosyl; synthetase yars1; yars1; trna synthetase ... See more keywords
On the Mechanism and Origin of Isoleucyl-tRNA Synthetase Editing against Norvaline.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.01.029
Abstract: Aminoacyl-tRNA synthetases (aaRSs), the enzymes responsible for coupling tRNAs to their cognate amino acids, minimize translational errors by intrinsic hydrolytic editing. Here, we compared norvaline (Nva), a linear amino acid not coded for protein synthesis,… read more here.
Keywords: editing nva; isoleucyl trna; trna synthetase; transfer editing ... See more keywords