Structural analyses of the malaria parasite aminoacyl‐tRNA synthetases provide new avenues for antimalarial drug discovery
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4148
Abstract: Malaria is a parasitic illness caused by the genus Plasmodium from the apicomplexan phylum. Five plasmodial species of P. falciparum (Pf), P. knowlesi, P. malariae, P. ovale, and P. vivax (Pv) are responsible for causing… read more here.
Keywords: structural analyses; antimalarial drug; drug; trna synthetases ... See more keywords
RNA mimicry in post‐transcriptional regulation by aminoacyl tRNA synthetases
Sign Up to like & getrecommendations! Published in 2019 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1564
Abstract: Aminoacyl tRNA synthetases (aaRS) are well studied for their roles in tRNA charging with cognate amino acid. Nevertheless, numerous lines of evidence indicate that these proteins have roles other than tRNA charging. These include coordination… read more here.
Keywords: transcriptional regulation; post transcriptional; trna synthetases; aminoacyl trna ... See more keywords
Cysteine Hydropersulfide Production Catalyzed by Cysteinyl-tRNA Synthetases
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.297
Abstract: We recently reported the production of a large quantity of reactive persulfides including cysteine hydropersulfide (CysSSH) in both prokaryotes and eukaryotes. Also, these reactive persulfides reportedly show critical functions for regulation of redox signaling. Currently,… read more here.
Keywords: trna synthetases; cysteine hydropersulfide; trna; cysteinyl trna ... See more keywords
Aminoacyl-tRNA synthetases of the multi-tRNA synthetase complex and their role in tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Translational Oncology"
DOI: 10.1016/j.tranon.2022.101392
Abstract: Highlights • Aminoacyl-tRNA synthetases (AARSs) of multi-tRNA synthetase complex (MSC) are involved in cancer pathogenesis.• The scaffolding proteins of MSC have mainly anti-tumorigenic functions whereas the MSC associated AARSs have pro-tumorigenic roles.• MSC release of… read more here.
Keywords: multi trna; aminoacyl trna; trna synthetases; trna synthetase ... See more keywords
Structural characterization of human aminoacyl-tRNA synthetases for translational and nontranslational functions.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2016.11.014
Abstract: Aminoacyl-tRNA synthetases (aaRSs) are enzymes that function at the first step of translation, catalyzing the conjugation of amino acids to their cognate tRNAs for protein synthesis. While preserving this essential role, higher eukaryotic aaRSs, such… read more here.
Keywords: nontranslational functions; trna synthetases; aminoacyl trna; translational nontranslational ... See more keywords
Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00134
Abstract: Aminoacyl-tRNA synthetases (aaRSs) are promising drug targets due to their essential roles in protein translation. Although current inhibitors primarily occupy one or two of the three substrate binding sites on aaRSs, we report here the… read more here.
Keywords: aminoacyl trna; triple site; proof concept; site ... See more keywords
Aminoacyl tRNA Synthetases: Implications of Structural Biology in Drug Development against Trypanosomatid Parasites
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00826
Abstract: The ensemble of aminoacyl tRNA synthetases is regarded as a key component of the protein translation machinery. With the progressive increase in structure-based studies on tRNA synthetase-ligand complexes, the detailed picture of these enzymes is… read more here.
Keywords: structural biology; trypanosomatid; development; trna synthetases ... See more keywords
Continuous directed evolution of aminoacyl-tRNA synthetases
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2474
Abstract: Directed evolution of orthogonal aminoacyl-tRNA synthetases (AARSs) enables site-specific installation of non-canonical amino acids (ncAAs) into proteins. Traditional evolution techniques typically produce AARSs with greatly reduced activity and selectivity compared to their wild-type counterparts. We… read more here.
Keywords: directed evolution; trna synthetases; aminoacyl trna; evolution ... See more keywords
Thermodynamic Analysis of Tyrosyl-tRNA Synthetases Revealed Bacterial-Selective Tyrosine Derivatives
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DOI: 10.1071/ch21218
Abstract: The non-proteinogenic amino acids m-fluorotyrosine and 2,4-dihydroxyphenylalanine demonstrated a respective 6- and 12-fold greater binding affinity to the purified tyrosyl-tRNA synthetase from Escherichia coli than that from human cytosol. The differential binding was identified by… read more here.
Keywords: thermodynamic analysis; synthetases revealed; analysis tyrosyl; revealed bacterial ... See more keywords
Distinct ways of G:U recognition by conserved tRNA binding motifs
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1807109115
Abstract: Significance Aminoacyl-tRNA synthetases (aaRSs) establish the rules to express the universal genetic code. During aminoacylation, each of the 20 aaRSs associates 1 of 20 amino acids with a specific trinucleotide known as anticodon. Remarkably, for… read more here.
Keywords: pair; base pair; recognition; trna synthetases ... See more keywords
RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1141
Abstract: Abstract Mitochondrial RNA metabolism is suggested to occur in identified compartmentalized foci, i.e. mitochondrial RNA granules (MRGs). Mitochondrial aminoacyl-tRNA synthetases (mito aaRSs) catalyze tRNA charging and are key components in mitochondrial gene expression. Mutations of… read more here.
Keywords: mito aarss; rna; trna synthetases; aminoacyl trna ... See more keywords