Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication.
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DOI: 10.1093/nar/gkab879
Abstract: Retroviral infection requires reverse transcription, and the reverse transcriptase (RT) uses cellular tRNA as its primer. In humans, the TRMT6-TRMT61A methyltransferase complex incorporates N1-methyladenosine modification at tRNA position 58 (m1A58); however, the role of m1A58… read more here.
Keywords: hiv replication; trna3lys; m1a58; steps hiv ... See more keywords