Naturally occurring dual recognition of tRNAHis substrates with and without a universal identity element
Sign Up to like & getrecommendations! Published in 2019 at "RNA Biology"
DOI: 10.1080/15476286.2019.1626663
Abstract: ABSTRACT The extra 5ʹ guanine nucleotide (G-1) on tRNAHis is a nearly universal feature that specifies tRNAHis identity. The G-1 residue is either genome encoded or post-transcriptionally added by tRNAHis guanylyltransferase (Thg1). Despite Caenorhabditis elegans… read more here.
Keywords: identity element; trnahis; recognition; universal identity ... See more keywords
Crystal structure of human cytoplasmic tRNAHis-specific 5′-monomethylphosphate capping enzyme
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz1216
Abstract: Abstract BCDIN3 domain containing RNA methyltransferase, BCDIN3D, monomethylates the 5′-monophosphate of cytoplasmic tRNAHis with a G−1:A73 mispair at the top of an eight-nucleotide-long acceptor helix, using S-adenosyl-l-methionine (SAM) as a methyl group donor. In humans,… read more here.
Keywords: crystal structure; trnahis; capping enzyme; cytoplasmic trnahis ... See more keywords
Recognition of tRNAHis in an RNase P-Free Nanoarchaeum
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DOI: 10.1128/spectrum.04621-22
Abstract: Mature tRNAHis has, at its 5′-terminus, an extra guanosine with 5′-monophosphate, designated G-1. G-1 is the major recognition element for histidyl-tRNA synthetase (HisRS), regardless of whether it is of eukaryotic or prokaryotic origin. ABSTRACT The… read more here.
Keywords: recognition; trnahis; monophosphate; nanoarchaeum ... See more keywords
Analysis of GTP addition in the reverse (3'-5') direction by human tRNAHis guanylyltransferase.
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DOI: 10.1261/rna.078287.120
Abstract: Human tRNAHis guanylyltransferase (HsThg1) catalyzes the 3'-5' addition of guanosine triphosphate (GTP) to the 5'-end (-1 position) of tRNAHis, producing mature tRNAHis In human cells, cytoplasmic and mitochondrial tRNAHis has adenine (A) or cytidine (C),… read more here.
Keywords: trnahis guanylyltransferase; trnahis; addition; human trnahis ... See more keywords