Structural and functional studies of rabbit SAMD9 reveal a distinct tRNase module that underlies the antiviral activity
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1013118
Abstract: Human SAMD9 and SAMD9L (collectively SAMD9/9L) are large cytoplasmic proteins with antiviral and antiproliferative activities, recently shown to regulate protein synthesis by specifically depleting phenylalanine tRNA (tRNAPhe). The enzymatic activity of human SAMD9 (hSAMD9) resides… read more here.
Keywords: rabbit samd9; antiviral activity; trnase; trnase module ... See more keywords
TRUE Gene Silencing
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DOI: 10.3390/ijms23105387
Abstract: TRUE gene silencing is an RNA-mediated gene expression control technology and is termed after tRNase ZL-utilizing efficacious gene silencing. In this review, I overview the potentiality of small guide RNA (sgRNA) for TRUE gene silencing… read more here.
Keywords: true gene; gene silencing; pre trna; trnase ... See more keywords