Structural and functional studies of rabbit SAMD9 reveal a distinct tRNase module that underlies the antiviral activity
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DOI: 10.1371/journal.ppat.1013118
Abstract: Human SAMD9 and SAMD9L (collectively SAMD9/9L) are large cytoplasmic proteins with antiviral and antiproliferative activities, recently shown to regulate protein synthesis by specifically depleting phenylalanine tRNA (tRNAPhe). The enzymatic activity of human SAMD9 (hSAMD9) resides… read more here.
Keywords: rabbit samd9; antiviral activity; trnase; trnase module ... See more keywords