Editor’s Highlight: An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx219
Abstract: We have developed an animal model of amodiaquine-induced liver injury that has characteristics very similar to idiosyncratic drug-induced liver injury (IDILI) in humans by impairing immune tolerance using a PD1-/- mouse and cotreatment with anti-CTLA-4.… read more here.
Keywords: troglitazone; tolcapone; pioglitazone; entacapone ... See more keywords
Crystallization of Four Troglitazone Isomers: Selectivity and Structural Considerations
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DOI: 10.3390/cryst15100866
Abstract: The control of crystal form in chiral active pharmaceutical ingredients (APIs) is a critical challenge in pharmaceutical development, as differences in solid-state structure can significantly influence physical properties and manufacturing performance. Troglitazone, a molecule with… read more here.
Keywords: troglitazone; troglitazone isomers; four troglitazone; solution ... See more keywords