A novel human monoclonal Trop2-IgG antibody inhibits ovarian cancer growth in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.028
Abstract: Trop2 is a tumor-related antigen closely related to the development of a variety of tumors and has been identified as a promising target for cancer immunotherapy. In this study, a Trop2-IgG antibody was constructed by… read more here.
Keywords: trop2; igg antibody; trop2 igg; tumor ... See more keywords
TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2113513
Abstract: ABSTRACT Introduction Breast cancer (BC) is the most common diagnosed cancer and the second leading cause of cancer-associated death in women, with the triple negative (TNBC) subtype being characterized by the poorest prognosis. New therapeutic… read more here.
Keywords: breast cancer; trop2; drug; cancer ... See more keywords
Abstract 2931: Functional characterization of KJ-103, a novel therapeutic anti-TROP2 heavy chain-only antibody
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2931
Abstract: Trophoblast cell surface antigen-2 (TROP2) is a membrane-bound protein expressed during development and at lower levels in normal adult tissues. In many solid tumors TROP2 upregulation is associated with increased tumor aggressiveness, metastasis, and decreased… read more here.
Keywords: heavy chain; anti trop2; trop2 heavy; trop2 ... See more keywords
Abstract 4430: Sacituzumab-Interferon beta mutein fusion protein, ABN202 (anti Trop2-interferon beta mutein), is a potent therapeutics for Trop-2-positive urothelial cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4430
Abstract: Background: Trop2, trophoblast cell-surface antigen 2, is a type 1 transmembrane glycoprotein overexpressed in many solid tumors such as breast, lung, pancreatic, gastric, colon, urothelial cancer. Overexpression of Trop2 is associated with aggressive disease progression… read more here.
Keywords: interferon beta; beta; beta mutein; trop2 ... See more keywords
Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Oncology"
DOI: 10.1159/000522592
Abstract: BACKGROUND Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in non-clear cell RCC, is still unclear. AIM… read more here.
Keywords: renal cell; trop2; trop2 expression; carcinoma ... See more keywords
TROP2 methylation and expression in tamoxifen-resistant breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Cell International"
DOI: 10.1186/s12935-018-0589-9
Abstract: BackgroundThe DNA methyltransferase 1 inhibitor, 5-Aza-2′-deoxycytidine (5-Aza-dC) is a potential treatment for breast cancer. However, not all breast tumors will respond similarly to treatment with 5-Aza-dC, and little is known regarding the response of hormone-resistant… read more here.
Keywords: methylation; breast; trop2; treatment ... See more keywords
EPCAM and TROP2 share a role in claudin stabilization and development of intestinal and extraintestinal epithelia in mice
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059403
Abstract: ABSTRACT Epithelial cell adhesion molecule (EPCAM) is a transmembrane glycoprotein expressed on the surface of most epithelial and epithelium-derived tumor cells and reported to regulate stability of epithelial tight junction proteins, claudins. Despite its widespread… read more here.
Keywords: development intestinal; trop2; epcam trop2; mice ... See more keywords
TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial–Mesenchymal Transition and Invasiveness
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14174137
Abstract: Trophoblastic cell surface antigen 2 (TROP2) is a membrane glycoprotein overexpressed in many solid tumors with poor prognosis, including intestinal neoplasms. In our study, we show that TROP2 is expressed in preneoplastic lesions and its… read more here.
Keywords: expression; crc; expression associated; trop2 ... See more keywords
Trop2 Forms a Stable Dimer with Significant Structural Differences within the Membrane-Distal Region as Compared to EpCAM
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910640
Abstract: Trop2 is a cell-surface transmembrane glycoprotein involved in the maintenance of epithelial tissue integrity and is an important carcinoma marker. It shares similar claudin-interaction capacity with its paralogue EpCAM, and both are implicated in signaling… read more here.
Keywords: trop2; dimer; forms stable; trop2 forms ... See more keywords
Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Oncology"
DOI: 10.3892/ijo.2018.4423
Abstract: Bladder cancer (BC) has become a serious health problem and represents the second most commonly diagnosed urological tumor. Curcumin is a principal active natural component of turmeric and has long been used in Asia as… read more here.
Keywords: cancer; cell proliferation; trop2; curcumin ... See more keywords
An anti-TROP2 monoclonal antibody TrMab-6 exerts antitumor activity in breast cancer mouse xenograft models
Sign Up to like & getrecommendations! Published in 2021 at "Oncology Reports"
DOI: 10.3892/or.2021.8083
Abstract: Trophoblast cell surface antigen 2 (TROP2), reported to be overexpressed in several types of cancer, is involved in cell proliferation, invasion, metastasis, and poor prognosis of many types of cancer. Previously, a highly sensitive anti-TROP2… read more here.
Keywords: trop2; breast cancer; trmab; cancer ... See more keywords