A novel human monoclonal Trop2-IgG antibody inhibits ovarian cancer growth in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.028
Abstract: Trop2 is a tumor-related antigen closely related to the development of a variety of tumors and has been identified as a promising target for cancer immunotherapy. In this study, a Trop2-IgG antibody was constructed by… read more here.
Keywords: trop2; igg antibody; trop2 igg; tumor ... See more keywords
Preclinical Evaluation of a Trop2-Targeted Peptide Probe for PET Imaging of Triple-Negative Breast Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.5c05242
Abstract: Trophoblast cell surface antigen 2 (Trop2) has been extensively characterized as a clinically relevant pan-cancer biomarker that is overexpressed in multiple malignancies, including triple-negative breast cancer (TNBC). In this study, we employed computational simulation strategies… read more here.
Keywords: pet imaging; breast cancer; negative breast; trop2 ... See more keywords
TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2113513
Abstract: ABSTRACT Introduction Breast cancer (BC) is the most common diagnosed cancer and the second leading cause of cancer-associated death in women, with the triple negative (TNBC) subtype being characterized by the poorest prognosis. New therapeutic… read more here.
Keywords: breast cancer; trop2; drug; cancer ... See more keywords
Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer Metastasis.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-24-4855
Abstract: Metastasis is the main cause of prostate cancer-associated deaths, highlighting the urgent need to determine the mechanisms underlying prostate cancer progression. TROP2 (also known as TACSTD2) is an oncogenic transmembrane surface protein that is highly… read more here.
Keywords: cancer; prostate cancer; trop2; metastasis ... See more keywords
Novel Amanitin-Based Antibody–Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-24-0266
Abstract: Abstract Trophoblast cell surface antigen 2 (TROP2) exhibits aberrant expression in pancreatic cancer, correlating with metastasis, advanced tumor stage, and poor prognosis in patients with pancreatic ductal adenocarcinoma. TROP2 has been recognized as a promising… read more here.
Keywords: cancer; trop2; antibody drug; pancreatic cancer ... See more keywords
Abstract A124: CBB-120: A TROP2-targeted dual-payload ADC combining Top1i and ATRi mechanisms demonstrates superior efficacy in preclinical models and improved safety in non-human primates
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-a124
Abstract: Antibody-drug conjugates (ADCs) have emerged as a powerful strategy for treating TROP2-expressing epithelial cancers, including breast and lung cancers. Among current therapies, Trodelvy® and Datroway® (Dato-DXd) carrying topoisomerase I inhibitors (Top1i) have demonstrated notable clinical… read more here.
Keywords: cbb 120; payload adc; trop2; top1i atri ... See more keywords
Abstract 2931: Functional characterization of KJ-103, a novel therapeutic anti-TROP2 heavy chain-only antibody
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2931
Abstract: Trophoblast cell surface antigen-2 (TROP2) is a membrane-bound protein expressed during development and at lower levels in normal adult tissues. In many solid tumors TROP2 upregulation is associated with increased tumor aggressiveness, metastasis, and decreased… read more here.
Keywords: heavy chain; anti trop2; trop2 heavy; trop2 ... See more keywords
Abstract 4430: Sacituzumab-Interferon beta mutein fusion protein, ABN202 (anti Trop2-interferon beta mutein), is a potent therapeutics for Trop-2-positive urothelial cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4430
Abstract: Background: Trop2, trophoblast cell-surface antigen 2, is a type 1 transmembrane glycoprotein overexpressed in many solid tumors such as breast, lung, pancreatic, gastric, colon, urothelial cancer. Overexpression of Trop2 is associated with aggressive disease progression… read more here.
Keywords: interferon beta; beta; beta mutein; trop2 ... See more keywords
Abstract 3136: Towards development of a novel biparatopic trop2-ADC
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3136
Abstract: Background: Trophoblast cell surface antigen 2 (TROP-2) is a member of Tumor-associated Calcium Signal Transducer family (TACSTD2), which is a 35kDa transmembrane protein with 4 N-linked glycosylation sites. The overexpression of TROP2 in various cancers… read more here.
Keywords: trop2 adc; trop2; cell; biparatopic ... See more keywords
Abstract 6757: The anti-tumor efficacy of Th1-specific TROP2 vaccine (AST-07X) in a triple-negative breast cancer murine model
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-6757
Abstract: Background: The trophoblast cell-surface antigen 2 (TROP2) is associated with enhanced tumor proliferation and poor prognosis in breast cancer. TROP2 overexpresses on various epithelial cancer cell surfaces, and is commonly found in prostate, colon, pancreas,… read more here.
Keywords: cancer; trop2; tumor; tumor efficacy ... See more keywords
Abstract 866: Identification of survival-associated epithelial cell markers linked to TROP2 through single-cell and bulk sequencing analysis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-866
Abstract: Introduction: Colorectal Cancer (CRC) is known for its aggressiveness and drug resistance. This has increased the interest in antibody-drug conjugates (ADCs) as a possible therapy. In this study, we aim to investigate the effects of… read more here.
Keywords: survival; analysis; risk; trop2 ... See more keywords