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   Articles with "trophoblast" as a keyword



Generation of Tpbpα-iCre-EGFP Knock-In Mice for Trophoblast Subtype-Specific Gene Manipulation.

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recommendations! Published in 2025 at "Genesis"

DOI: 10.1002/dvg.70034

Abstract: The placenta plays an essential role during pregnancy in mammals, with the placental endocrine trophoblast subtypes secreting many growth factors and cytokines to promote fetal growth and maternal adaptation. These endocrine cells, including trophoblast giant… read more here.

Keywords: mice; egfp knock; icre egfp; trophoblast ... See more keywords

Sodium tanshinone IIA sulfonate prevents hypoxic trophoblast‐induced endothelial cell dysfunction via targeting HMGB1 release

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recommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.21903

Abstract: Preeclampsia (PE) is a serious blood pressure disorder of pregnancy. Systemic endothelial cell dysfunction, a hallmark of PE, is previously estimated to be induced by hypoxic trophoblast high mobility group box 1 (HMGB1). In the… read more here.

Keywords: dysfunction; endothelial cell; tanshinone iia; hypoxic trophoblast ... See more keywords

LIN28B regulates androgen receptor in human trophoblast cells through Let‐7c

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recommendations! Published in 2019 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.23226

Abstract: LIN28B is an RNA‐binding protein necessary for maintaining pluripotency in stem cells and plays an important role in trophoblast cell differentiation. LIN28B action on target gene function often involves the Let‐7 miRNA family. Previous work… read more here.

Keywords: lin28b; trophoblast; cells let; trophoblast cells ... See more keywords
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RACK1 may participate in placental development at mid‐gestation via regulating trophoblast cell proliferation and migration in pigs

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recommendations! Published in 2023 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.23680

Abstract: Intrauterine growth restriction (IUGR) is a severe complication in swine production. Placental insufficiency is responsible for inadequate fetal growth, but the specific etiology of placental dysfunction‐induced IUGR in pigs remains poorly understood. In this work,… read more here.

Keywords: development; proliferation migration; rack1 may; trophoblast ... See more keywords

Sequestration of eIF4A by angiomotin: A novel mechanism to restrict global protein synthesis in trophoblast cells

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recommendations! Published in 2020 at "STEM CELLS"

DOI: 10.1002/stem.3305

Abstract: Enrichment of angiomotin (AMOT) in the ectoplacental cone of E7.5 murine placenta prompted our investigation on the role of AMOT in trophoblast differentiation. We show here that AMOT levels increased in mouse placenta during gestation… read more here.

Keywords: eif4a; trophoblast; protein synthesis; amot ... See more keywords
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Direct Reprogramming of Mouse Embryonic Fibroblasts to Induced Trophoblast Stem Cells.

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recommendations! Published in 2020 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-0301-7_18

Abstract: Trophoblast cells are the first committed lineage to emerge during mammalian preimplantation embryo development. Trophoblast stem (TS) cells can be derived from the trophectoderm (TE) of blastocyst-stage embryos and differentiate into extraembryonic trophoblast cells of the… read more here.

Keywords: induced trophoblast; trophoblast; stem cells; trophoblast stem ... See more keywords

Human placenta and trophoblast development: key molecular mechanisms and model systems

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recommendations! Published in 2019 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-019-03104-6

Abstract: Abnormal placentation is considered as an underlying cause of various pregnancy complications such as miscarriage, preeclampsia and intrauterine growth restriction, the latter increasing the risk for the development of severe disorders in later life such… read more here.

Keywords: model systems; human placenta; placenta trophoblast; trophoblast ... See more keywords

Optimization of in vitro trophoblast assay for real-time impedimetric sensing of trophoblast-erythrocyte interactions in Plasmodium falciparum malaria

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recommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-020-02413-1

Abstract: Sequestration of Plasmodium falciparum–infected erythrocytes (IEs) is responsible for the pathophysiology of placental malaria, leading to serious complications such as intrauterine growth restriction and low birth weight. However, it is an experimental challenge to study… read more here.

Keywords: real time; time; plasmodium falciparum; trophoblast ... See more keywords

Derivation of human triploid trophoblast stem cells

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recommendations! Published in 2022 at "Journal of Assisted Reproduction and Genetics"

DOI: 10.1007/s10815-022-02436-w

Abstract: Human trophoblast stem cells (hTSCs) are counterparts of the precursor cells of the placenta and are valuable cell models for the study of placental development and the pathogenesis of placental diseases. The aim of this… read more here.

Keywords: trophoblast; derivation human; stem cells; trophoblast stem ... See more keywords

LncRNA-NEAT1 blocks the Wnt/β-catenin signaling pathway by targeting miR-217 to inhibit trophoblast cell migration and invasion

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recommendations! Published in 2024 at "Journal of Assisted Reproduction and Genetics"

DOI: 10.1007/s10815-024-03124-7

Abstract: This study aimed to study the correlation between preeclampsia (PE) and lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1), and to examine the molecular mechanisms behind the development of PE. 30 PE and 30 normal pregnant… read more here.

Keywords: migration; mir 217; cell; trophoblast ... See more keywords
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Ubiquitin-Specific Peptidase 5 is Involved in the Proliferation of Trophoblast Cells by Regulating Wnt/β-Catenin Signaling

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recommendations! Published in 2021 at "Molecular Biotechnology"

DOI: 10.1007/s12033-021-00330-x

Abstract: Preeclampsia (PE) is a pathologic condition in pregnant women which accounts for the inhibition of proliferation, migration and invasion of trophoblast cells. This study aimed to investigate the regulation of ubiquitin-specific peptidase 5 (USP5) on… read more here.

Keywords: trophoblast cells; ubiquitin specific; catenin; proliferation trophoblast ... See more keywords