Sodium tanshinone IIA sulfonate prevents hypoxic trophoblast‐induced endothelial cell dysfunction via targeting HMGB1 release
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21903
Abstract: Preeclampsia (PE) is a serious blood pressure disorder of pregnancy. Systemic endothelial cell dysfunction, a hallmark of PE, is previously estimated to be induced by hypoxic trophoblast high mobility group box 1 (HMGB1). In the… read more here.
Keywords: dysfunction; endothelial cell; tanshinone iia; hypoxic trophoblast ... See more keywords
LIN28B regulates androgen receptor in human trophoblast cells through Let‐7c
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23226
Abstract: LIN28B is an RNA‐binding protein necessary for maintaining pluripotency in stem cells and plays an important role in trophoblast cell differentiation. LIN28B action on target gene function often involves the Let‐7 miRNA family. Previous work… read more here.
Keywords: lin28b; trophoblast; cells let; trophoblast cells ... See more keywords
RACK1 may participate in placental development at mid‐gestation via regulating trophoblast cell proliferation and migration in pigs
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23680
Abstract: Intrauterine growth restriction (IUGR) is a severe complication in swine production. Placental insufficiency is responsible for inadequate fetal growth, but the specific etiology of placental dysfunction‐induced IUGR in pigs remains poorly understood. In this work,… read more here.
Keywords: development; proliferation migration; rack1 may; trophoblast ... See more keywords
Sequestration of eIF4A by angiomotin: A novel mechanism to restrict global protein synthesis in trophoblast cells
Sign Up to like & getrecommendations! Published in 2020 at "STEM CELLS"
DOI: 10.1002/stem.3305
Abstract: Enrichment of angiomotin (AMOT) in the ectoplacental cone of E7.5 murine placenta prompted our investigation on the role of AMOT in trophoblast differentiation. We show here that AMOT levels increased in mouse placenta during gestation… read more here.
Keywords: eif4a; trophoblast; protein synthesis; amot ... See more keywords
Direct Reprogramming of Mouse Embryonic Fibroblasts to Induced Trophoblast Stem Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0301-7_18
Abstract: Trophoblast cells are the first committed lineage to emerge during mammalian preimplantation embryo development. Trophoblast stem (TS) cells can be derived from the trophectoderm (TE) of blastocyst-stage embryos and differentiate into extraembryonic trophoblast cells of the… read more here.
Keywords: induced trophoblast; trophoblast; stem cells; trophoblast stem ... See more keywords
Human placenta and trophoblast development: key molecular mechanisms and model systems
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03104-6
Abstract: Abnormal placentation is considered as an underlying cause of various pregnancy complications such as miscarriage, preeclampsia and intrauterine growth restriction, the latter increasing the risk for the development of severe disorders in later life such… read more here.
Keywords: model systems; human placenta; placenta trophoblast; trophoblast ... See more keywords
Optimization of in vitro trophoblast assay for real-time impedimetric sensing of trophoblast-erythrocyte interactions in Plasmodium falciparum malaria
Sign Up to like & getrecommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-02413-1
Abstract: Sequestration of Plasmodium falciparum–infected erythrocytes (IEs) is responsible for the pathophysiology of placental malaria, leading to serious complications such as intrauterine growth restriction and low birth weight. However, it is an experimental challenge to study… read more here.
Keywords: real time; time; plasmodium falciparum; trophoblast ... See more keywords
Derivation of human triploid trophoblast stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-022-02436-w
Abstract: Human trophoblast stem cells (hTSCs) are counterparts of the precursor cells of the placenta and are valuable cell models for the study of placental development and the pathogenesis of placental diseases. The aim of this… read more here.
Keywords: trophoblast; derivation human; stem cells; trophoblast stem ... See more keywords
Ubiquitin-Specific Peptidase 5 is Involved in the Proliferation of Trophoblast Cells by Regulating Wnt/β-Catenin Signaling
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DOI: 10.1007/s12033-021-00330-x
Abstract: Preeclampsia (PE) is a pathologic condition in pregnant women which accounts for the inhibition of proliferation, migration and invasion of trophoblast cells. This study aimed to investigate the regulation of ubiquitin-specific peptidase 5 (USP5) on… read more here.
Keywords: trophoblast cells; ubiquitin specific; catenin; proliferation trophoblast ... See more keywords
HDAC4 Knockdown Induces Preeclampsia Cell Autophagy and Apoptosis by miR-29b
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00286-4
Abstract: Preeclampsia (PE) is one of the main causes of maternal death and perinatal morbidity and mortality. Considering that histone deacetylase 4 (HDAC4) activity could relate to trophoblast cell motility and be antagonized by miR-29b, the… read more here.
Keywords: autophagy apoptosis; hdac4; trophoblast; mir 29b ... See more keywords
Transcription Factors That Regulate Trophoblast Development and Function.
Sign Up to like & getrecommendations! Published in 2017 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2016.12.003
Abstract: The placenta is a transient organ that plays a critical role in sustaining pregnancy and supporting fetal growth and nutrition. The placental epithelium is comprised of trophoblast cells. Trophoblast cells are the first cell type… read more here.
Keywords: trophoblast; function; regulate trophoblast; factors regulate ... See more keywords