TGF-β1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.12.004
Abstract: Cadherins are transmembrane proteins that mediate cell-cell adhesion by promoting the formation of adherens junctions. The regulated expression of cadherins is thought to play important roles in both normal and diseased placental development. Cadherin-11, also… read more here.
Keywords: cadherin expression; tgf; expression; trophoblast cell ... See more keywords
Invasion of trophoblast cell lines is inhibited by miR-93 via MMP-2.
Sign Up to like & getrecommendations! Published in 2017 at "Placenta"
DOI: 10.1016/j.placenta.2017.03.008
Abstract: Preeclampsia (PE) is a serious pregnancy-related syndrome, which is characterized by gestational hypertension and proteinuria. The microRNA-93 (miR-93) is upregulated in the maternal plasma of patients with PE. However, the functional role of miR-93 in… read more here.
Keywords: invasion; cell lines; mir; trophoblast cell ... See more keywords
Single-nuclei RNA sequencing (snRNA-seq) uncovers trophoblast cell types and lineages in the mature bovine placenta.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221526120
Abstract: Ruminants have a semi-invasive placenta, which possess highly vascularized placentomes formed by maternal endometrial caruncles and fetal placental cotyledons and required for fetal development to term. The synepitheliochorial placenta of cattle contains at least two… read more here.
Keywords: cell; trophoblast cell; cell types; placenta ... See more keywords
Involvement of WNT2 in trophoblast cell behavior in preeclampsia development
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1802913
Abstract: ABSTRACT This study aimed to determine the WNT2 expression in patients with severe preeclampsia and to explore the function of WNT2 dysregulation on the biological behaviors of trophoblast cells. The WNT2 and β-catenin expression in… read more here.
Keywords: trophoblast cell; preeclampsia; expression; wnt2 ... See more keywords
Forkhead-box C1 attenuates high glucose-induced trophoblast cell injury during gestational diabetes mellitus via activating adenosine monophosphate-activated protein kinase through regulating fibroblast growth factor 19
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2018094
Abstract: ABSTRACT Gestational diabetes mellitus (GDM) is a complication developed during pregnancy and recover after childbirth. The purpose of this study was to investigate the protective role of FOXC1 during GDM and the underlying mechanism. FOXC1… read more here.
Keywords: cell; trophoblast cell; gestational diabetes; diabetes mellitus ... See more keywords
MicroRNA-135b-5p regulates trophoblast cell function by targeting phosphoinositide-3-kinase regulatory subunit 2 in preeclampsia
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2073655
Abstract: ABSTRACT The level of miR‑135b-5p is lower in patients with preeclampsia (PE) superimposed on chronic hypertension than in healthy controls. However, the function of miR‑135b-5p in PE progression remains unknown. In the present study, we… read more here.
Keywords: trophoblast cell; function targeting; cell function; mir 135b ... See more keywords
EZH2 enhances proliferation and migration of trophoblast cell lines by blocking GADD45A-mediated p38/MAPK signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2074620
Abstract: ABSTRACT Impaired activity of the trophoblasts is a major contributor to the progression of pregnancy pathologies including preeclampsia (PE). This research probed the function of enhancer of zeste homolog 2 (EZH2) in activity of trophoblast… read more here.
Keywords: trophoblast cell; mapk signaling; gadd45a; trophoblast ... See more keywords
Circ_0007611 stimulates IL-1 receptor accessory protein to inhibit trophoblast cell proliferation and induce cell apoptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Biology of reproduction"
DOI: 10.1093/biolre/ioac028
Abstract: Preeclampsia (PE) is a common pregnancy disorder, and mounting evidence has revealed that circular RNA participates in PE development. However, the detailed molecular mechanism of circ_0007611 in PE progression remains unknown. RNA expressions of circ_0007611,… read more here.
Keywords: cell proliferation; cell apoptosis; circ 0007611; cell ... See more keywords
Circ_0001326 suppresses trophoblast cell proliferation, invasion, migration and epithelial–mesenchymal transition progression in preeclampsia by miR-188-3p/HtrA serine peptidase 1 axis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000003373
Abstract: Background: It has been reported that the alteration of circular RNAs (circRNAs) during preeclampsia (PE) can be associated with the pathogenesis of this disease. Herein, this work investigated the potential functions and mechanism of circ_0001326… read more here.
Keywords: invasion migration; mir 188; circ 0001326; trophoblast cell ... See more keywords
Gingival crevicular fluid from pregnant women impairs trophoblast cell function and trophoblast‐neutrophil interaction
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13558
Abstract: A strong association between periodontitis and higher susceptibility to pregnancy complications like preeclampsia has been reported although the mechanisms remain elusive. Trophoblast cells modulate the recruitment and functional shaping of maternal leukocytes at early stages… read more here.
Keywords: function trophoblast; trophoblast cell; cell function; crevicular fluid ... See more keywords
Differential Expression of miR-136 in Gestational Diabetes Mellitus Mediates the High-Glucose-Induced Trophoblast Cell Injury through Targeting E2F1
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Genomics"
DOI: 10.1155/2020/3645371
Abstract: Background Gestational diabetes mellitus (GDM) seriously affects the health of mothers and infants. The high-glucose-induced inhibition in trophoblast cell viability is an important event in GDM pathogenesis. This study evaluated the expression and clinical significance… read more here.
Keywords: high glucose; expression; trophoblast; trophoblast cell ... See more keywords