Circ‐OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR‐558/THBS2 axis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21931
Abstract: Preeclampsia (PE) is one of the most serious diseases during pregnancy. Circular RNAs (circRNAs) are strongly related to the occurrence of preeclampsia. Herein, we aimed to explore the potential role and mechanism of circRNA oligophrenin… read more here.
Keywords: thbs2; mir 558; circ ophn1; circ ... See more keywords
MicroRNA‐576‐5p enhances the invasion ability of trophoblast cells in preeclampsia by targeting TFAP2A
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1025
Abstract: Preeclampsia (PE) is a common pregnancy‐related syndrome characterized by hypertension and proteinuria, and a major cause of maternal mortality. Therefore, there is an urgent need to identify early biomarkers of PE. The aim of the… read more here.
Keywords: invasion ability; enhances invasion; trophoblast cells; microrna 576 ... See more keywords
LIN28B regulates androgen receptor in human trophoblast cells through Let‐7c
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23226
Abstract: LIN28B is an RNA‐binding protein necessary for maintaining pluripotency in stem cells and plays an important role in trophoblast cell differentiation. LIN28B action on target gene function often involves the Let‐7 miRNA family. Previous work… read more here.
Keywords: lin28b; trophoblast; cells let; trophoblast cells ... See more keywords
Sequestration of eIF4A by angiomotin: A novel mechanism to restrict global protein synthesis in trophoblast cells
Sign Up to like & getrecommendations! Published in 2020 at "STEM CELLS"
DOI: 10.1002/stem.3305
Abstract: Enrichment of angiomotin (AMOT) in the ectoplacental cone of E7.5 murine placenta prompted our investigation on the role of AMOT in trophoblast differentiation. We show here that AMOT levels increased in mouse placenta during gestation… read more here.
Keywords: eif4a; trophoblast; protein synthesis; amot ... See more keywords
Cytotoxic Activity of Peripheral Blood NK Cells towards Trophoblast Cells during Pregnancy
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04393-4
Abstract: We evaluated cytotoxic activity of peripheral blood NK cells towards trophoblast cells. NK cells either isolated or in the composition of mononuclear cell fraction, caused death of trophoblast cells. In women with physiological pregnancy, the… read more here.
Keywords: trophoblast cells; activity peripheral; cytotoxic activity;
Ubiquitin-Specific Peptidase 5 is Involved in the Proliferation of Trophoblast Cells by Regulating Wnt/β-Catenin Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biotechnology"
DOI: 10.1007/s12033-021-00330-x
Abstract: Preeclampsia (PE) is a pathologic condition in pregnant women which accounts for the inhibition of proliferation, migration and invasion of trophoblast cells. This study aimed to investigate the regulation of ubiquitin-specific peptidase 5 (USP5) on… read more here.
Keywords: trophoblast cells; ubiquitin specific; catenin; proliferation trophoblast ... See more keywords
NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells.
Sign Up to like & getrecommendations! Published in 2021 at "Immunobiology"
DOI: 10.1016/j.imbio.2021.152125
Abstract: NK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The… read more here.
Keywords: cell; presence; trophoblast cells; function ... See more keywords
Leukemia inhibitory factor regulates the activation of inflammatory signals in macrophages and trophoblast cells.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.01.021
Abstract: The pleiotropic cytokine leukemia inhibitory factor (LIF) is a key gestational factor known to establish dynamic cellular and molecular cross talk at the feto-maternal interface. Previously, we described the regulatory role of the LIF-trophoblast-IL10 axis… read more here.
Keywords: macrophage; trophoblast cells; activation; factor ... See more keywords
Loss of selenocysteine insertion sequence binding protein 2 suppresses the proliferation, migration/invasion and hormone secretion of human trophoblast cells via the PI3K/Akt and ERK signaling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Placenta"
DOI: 10.1016/j.placenta.2017.05.007
Abstract: INTRODUCTION Selenocysteine insertion binding protein 2 (SECISBP2) plays a vital role in selenocysteine incorporation into selenoprotein in many creatures. However, the impact of SECISBP2 in development of trophoblast cells remains unclear. The aim of this… read more here.
Keywords: proliferation migration; trophoblast cells; pi3k akt; trophoblast ... See more keywords
Molecular regulation of vascular smooth muscle cell phenotype switching by trophoblast cells at the maternal-fetal interface.
Sign Up to like & getrecommendations! Published in 2020 at "Placenta"
DOI: 10.1016/j.placenta.2020.02.017
Abstract: INTRODUCTION Establishment of hemochorial placenta is associated with development and remodelling of uterine vasculature at the maternal fetal interface. This results in calibration of high resistance uterine arteries to flaccid low resistance vessels resulting in… read more here.
Keywords: trophoblast cells; vascular smooth; phenotype switching; smooth muscle ... See more keywords
Acetaminophen Attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cells.
Sign Up to like & getrecommendations! Published in 2020 at "Placenta"
DOI: 10.1016/j.placenta.2020.12.002
Abstract: Acetaminophen is one of the most common medications taken during pregnancy, considered safe for maternal health and fetal development. However, recent epidemiological studies have associated prenatal acetaminophen use with several developmental disorders in offspring. As… read more here.
Keywords: acetaminophen; invasion; trimester trophoblast; trophoblast ... See more keywords