Extracellular vesicles secreted by human uterine stromal cells regulate decidualization, angiogenesis, and trophoblast differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200252119
Abstract: Significance A major challenge in reproductive sciences today is to decipher the molecular basis of cell–cell communication during early pregnancy. The present study reveals that extracellular vesicles (EVs) generated by human endometrial stromal cells carry… read more here.
Keywords: extracellular vesicles; trophoblast differentiation; decidualization; decidualization angiogenesis ... See more keywords
The multifaceted role of GCM1 during trophoblast differentiation in the human placenta
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203071119
Abstract: Significance Proper placental development is critical for pregnancy success. Placental maldevelopment is linked with serious pregnancy complications that jeopardize the health of both mother and child. The parenchymal cells of the placenta are trophoblasts, which… read more here.
Keywords: gcm1 trophoblast; role; trophoblast differentiation; gcm1 ... See more keywords
The roles of ADAMDEC1 in trophoblast differentiation during normal pregnancy and preeclampsia.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaac014
Abstract: Human cytotrophoblast differentiation into syncytiotrophoblast is essential for placental formation and function. Understanding the molecular mechanisms involved in trophoblast differentiation is necessary as it would help in the development of novel therapeutic agents to treat… read more here.
Keywords: roles adamdec1; adamdec1 trophoblast; trophoblast differentiation; preeclampsia ... See more keywords
Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2
Sign Up to like & getrecommendations! Published in 2020 at "BMC Biology"
DOI: 10.1186/s12915-020-00883-4
Abstract: Background Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development. Hyperactivation of Wnt signaling has been shown to be associated with human trophoblast… read more here.
Keywords: wnt signaling; trophoblast differentiation; sfrp1 sfrp5; differentiation ... See more keywords
TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc17069
Abstract: Background Transforming growth factor beta (TGF-β) signaling has been shown to control a large number of critical cellular actions such as cell death, differentiation, and development and has been implicated as a major regulator of… read more here.
Keywords: trophoblast differentiation; sm10; tgf; differentiation ... See more keywords
Metformin impairs trophoblast metabolism and differentiation in a dose-dependent manner.
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in cell and developmental biology"
DOI: 10.3389/fcell.2023.1167097
Abstract: Metformin is a widely prescribed medication whose mechanism of action is not completely defined and whose role in gestational diabetes management remains controversial. In addition to increasing the risk of fetal growth abnormalities and preeclampsia,… read more here.
Keywords: trophoblast differentiation; metabolism differentiation; differentiation; trophoblast metabolism ... See more keywords