Human placenta‐derived mesenchymal stem cells induce trophoblast invasion via dynamic effects on mitochondrial function
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30330
Abstract: The trophoblast is a critical cell for placental development and embryo implantation in the placenta. We previously reported that placenta‐derived mesenchymal stem cells (PD‐MSCs) increase trophoblast invasion through several signaling pathways. However, the paracrine effects… read more here.
Keywords: derived mesenchymal; trophoblast invasion; invasion; mitochondrial function ... See more keywords
The regulation of trophoblast invasion and decidual reaction by matrix metalloproteinase‐2, metalloproteinase‐7, and metalloproteinase‐9 expressions in the rat endometrium
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12342
Abstract: We aimed to evaluate how matrix metalloproteinases (MMPs) regulate the trophoblast invasion and placentation. read more here.
Keywords: trophoblast invasion; metalloproteinase; matrix; metalloproteinase metalloproteinase ... See more keywords
Nicotine Suppresses the Invasiveness of Human Trophoblasts by Downregulation of CXCL12 Expression through the Alpha-7 Subunit of the Nicotinic Acetylcholine Receptor
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-019-00095-4
Abstract: Smoke exposure during pregnancy has detrimental effects upon numerous fetal and neonatal outcomes. Nicotine (the main component of tobacco) has been suggested to affect placental development. During placental development, efficient invasion by trophoblasts is required… read more here.
Keywords: invasion; trophoblast invasion; cxcl12 expression; nicotinic acetylcholine ... See more keywords
Indoleamine 2,3-dioxygenase and trophoblast invasion in caesarean scar pregnancy: Implications for the aetiopathogenesis of placenta accreta spectrum.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2020.103099
Abstract: Immunohistochemical localisation of indoleamine 2,3-dioxygenase was studied in order to better understand the pathophysiology of placenta accreta spectrum. In the decidua staining for indoleamine 2,3-dioxygenase was found in the glandular epithelium with some additional positive… read more here.
Keywords: accreta spectrum; trophoblast invasion; dioxygenase; indoleamine dioxygenase ... See more keywords
Bisphenol A affects trophoblast invasion by inhibiting CXCL8 expression in decidual stromal cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.07.016
Abstract: Bisphenol A (BPA), an environmental endocrine-disrupting organic chemical, has been positively associated with the rate of implantation failure of in vitro fertilization. However, the underlying mechanisms remain unclear. To reveal the impact and the underlying mechanism… read more here.
Keywords: cxcl8 expression; trophoblast invasion; invasion; stromal cells ... See more keywords
Up-regulation of PTEN via LPS/AP-1/NF-κB pathway inhibits trophoblast invasion contributing to preeclampsia.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.12.018
Abstract: Preeclampsia, a pregnancy-specific disorder, is characterized by abnormal vascular remodeling of the spiral arteries due to deficient trophoblast invasion. Lipopolysaccharide (LPS) administration to pregnant rats on day 5 of pregnancy could induce excessive immune response… read more here.
Keywords: invasion; trophoblast invasion; expression pten; expression ... See more keywords
Investigation of human trophoblast invasion in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Human reproduction update"
DOI: 10.1093/humupd/dmaa017
Abstract: BACKGROUND In humans, inadequate trophoblast invasion into the decidua is associated with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction (FGR) and stillbirth. The mechanisms regulating invasion remain poorly understood, although interactions with… read more here.
Keywords: invasion; trophoblast invasion; cell lines; evt ... See more keywords
Extravillous trophoblast invasion and decidualization in cesarean scar pregnancies
Sign Up to like & getrecommendations! Published in 2022 at "Acta Obstetricia et Gynecologica Scandinavica"
DOI: 10.1111/aogs.14435
Abstract: The increasing cesarean section rate has led to an increase in the number of subsequent pregnancies resulting in a cesarean scar pregnancy. There appears to be preferential attachment of the blastocyst to the scar site,… read more here.
Keywords: invasion decidualization; scar; trophoblast invasion; decidualization cesarean ... See more keywords
IGFBP7 enhances trophoblast invasion via IGF-1R/c-Jun signaling in unexplained recurrent spontaneous abortion.
Sign Up to like & getrecommendations! Published in 2022 at "Reproduction"
DOI: 10.1530/rep-21-0501
Abstract: Insufficient trophoblast invasion at the maternal-fetal interface contributes to abortion-prone pregnancy. Cyclosporine A (CsA) can exert therapeutic effects on unexplained recurrent spontaneous abortion (URSA) by promoting trophoblast invasion. A previous study showed decreased expression of… read more here.
Keywords: abortion; trophoblast invasion; expression; igfbp7 ... See more keywords
Porphyromonas gingivalis Suppresses Trophoblast Invasion by Soluble Factors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Periodontology"
DOI: 10.1902/jop.2017.170193
Abstract: BACKGROUND Periodontitis is a common chronic inflammatory disorder that affects supporting tissues of the teeth. An increased risk of pregnancy complications has been reported in patients with periodontitis; however, its pathophysiology remains uncharacterized to date.… read more here.
Keywords: microscopy; invasion; trophoblast invasion; porphyromonas gingivalis ... See more keywords
Preeclampsia is Associated With Reduced ISG15 Levels Impairing Extravillous Trophoblast Invasion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.898088
Abstract: Among several interleukin (IL)-6 family members, only IL-6 and IL-11 require a gp130 protein homodimer for intracellular signaling due to lack of intracellular signaling domain in the IL-6 receptor (IL-6R) and IL-11R. We previously reported… read more here.
Keywords: isg15 levels; trophoblast invasion; expression; invasion ... See more keywords