Direct Reprogramming of Mouse Embryonic Fibroblasts to Induced Trophoblast Stem Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0301-7_18
Abstract: Trophoblast cells are the first committed lineage to emerge during mammalian preimplantation embryo development. Trophoblast stem (TS) cells can be derived from the trophectoderm (TE) of blastocyst-stage embryos and differentiate into extraembryonic trophoblast cells of the… read more here.
Keywords: induced trophoblast; trophoblast; stem cells; trophoblast stem ... See more keywords
Derivation of human triploid trophoblast stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-022-02436-w
Abstract: Human trophoblast stem cells (hTSCs) are counterparts of the precursor cells of the placenta and are valuable cell models for the study of placental development and the pathogenesis of placental diseases. The aim of this… read more here.
Keywords: trophoblast; derivation human; stem cells; trophoblast stem ... See more keywords
MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.030
Abstract: The first epithelial-to-mesenchymal transition (EMT) occurs in trophoblast stem (TS) cells during implantation. Inactivation of the serine/threonine kinase MAP3K4 in TS cells (TSKI4 cells) induces an intermediate state of EMT, where cells retain stemness, lose… read more here.
Keywords: mesenchymal transition; map3k4; epithelial mesenchymal; hdac6 ... See more keywords
A potential role of galectin-1 in promoting mouse trophoblast stem cell differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.11.003
Abstract: Galectin-1 is highly expressed in blastocysts and trophoblast giant cells during implantation, and dysregulated galectin-1 is associated with many pregnancy-related abnormalities. Elevated galectin-1 contributes to cancer cells invasion. Here, we found that galectin-1 is expressed… read more here.
Keywords: galectin; differentiation; potential role; trophoblast stem ... See more keywords
Derivation of Human Trophoblast Stem Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cell stem cell"
DOI: 10.1016/j.stem.2017.11.004
Abstract: Trophoblast cells play an essential role in the interactions between the fetus and mother. Mouse trophoblast stem (TS) cells have been derived and used as the best in vitro model for molecular and functional analysis of… read more here.
Keywords: stem cells; human trophoblast; trophoblast; stem ... See more keywords
Efficient Induction of Syncytiotrophoblast Layer II Cells from Trophoblast Stem Cells by Canonical Wnt Signaling Activation
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2017.10.014
Abstract: Summary The syncytiotrophoblast layer is the most critical and prominent tissue in placenta. SynT cells are differentiated from trophoblast stem cells (TSCs) during early embryogenesis. Mouse TSCs can spontaneously differentiate into cells of mixed lineages… read more here.
Keywords: synt cells; syncytiotrophoblast layer; layer; synt ... See more keywords
Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63602-7
Abstract: The placenta forms a maternal-fetal junction that supports many physiological functions such as the supply of nutrition and exchange of gases and wastes. Establishing an in vitro culture model of human and non-human primate trophoblast… read more here.
Keywords: cell lines; stem cell; trophoblast; stem ... See more keywords
MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2105130118
Abstract: Significance The human placenta contains progenitors that give rise to highly specialized trophoblast cell types, and failures in their differentiation are associated with placental pathologies. Importantly, transcription factors controlling these cell fate decisions in humans… read more here.
Keywords: trophoblast stem; msx2; trophoblast; swi snf ... See more keywords
Wnt3a Activates the WNT-YAP/TAZ Pathway to Sustain CDX2 Expression in Bovine Trophoblast Stem Cells.
Sign Up to like & getrecommendations! Published in 2019 at "DNA and cell biology"
DOI: 10.1089/dna.2018.4458
Abstract: Trophoblast stem cells (TSCs), the precursors of placental cells, are effective for studying placental formation in vitro. Using a dual inhibition (2i) medium and mixed L-Wnt3a/mouse embryonic fibroblast feeder cells, we previously established the bovine… read more here.
Keywords: yap taz; bovine; wnt yap; trophoblast stem ... See more keywords
Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjy054
Abstract: Trophoblast stem cells (TSCs), which can be derived from the trophoectoderm of a blastocyst, have the ability to sustain self-renewal and differentiate into various placental trophoblast cell types. Meanwhile, essential insights into the molecular mechanisms… read more here.
Keywords: esrrb; self renewal; differentiation; tscs ... See more keywords
Self‐assembled human placental model from trophoblast stem cells in a dynamic organ‐on‐a‐chip system
Sign Up to like & getrecommendations! Published in 2023 at "Cell Proliferation"
DOI: 10.1111/cpr.13469
Abstract: The placental barrier plays a key role in protecting the developing fetus from xenobiotics and exchanging substances between the fetus and mother. However, the trophoblast cell lines and animal models are often inadequate to recapitulate… read more here.
Keywords: placental barrier; trophoblast stem; human placental; model ... See more keywords