Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad109
Abstract: Endogenous retroviruses (ERVs) have been proposed as a driving force for the evolution of the mammalian placenta, however, the contribution of ERVs to placental development and the underlying regulatory mechanism remain largely elusive. A key… read more here.
Keywords: trophoblast syncytialization; human trophoblast; derived enhancers; placental development ... See more keywords
S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.860261
Abstract: Recurrent pregnancy loss (RPL) is a severe complication of pregnancy that is caused by genetic abnormalities, immune dysfunction, aberrant cell biology, and tissue structure destruction. Among which, placental dysfunction is crucial in the pathogenetic progression… read more here.
Keywords: rpl; development; syncytialization; pregnancy ... See more keywords
Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction
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DOI: 10.3389/fendo.2023.1107182
Abstract: Placental dysfunction refers to the insufficiency of placental perfusion and chronic hypoxia during early pregnancy, which impairs placental function and causes inadequate supply of oxygen and nutrients to the fetus, affecting fetal development and health.… read more here.
Keywords: trophoblast syncytialization; growth restriction; intrauterine growth; syncytialization ... See more keywords
Alpha 1 Antitrypsin Regulates Trophoblast Syncytialization and Inflammatory Factor Expression
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DOI: 10.3390/ijms23041955
Abstract: The serine protease inhibitor alpha1-antitrypsin (A1AT) may possess protective functions of impaired organs in a manner independent of its protease inhibitor activity. A1AT expression has been shown to fluctuate in patients with pregnancy-induced hypertension, which… read more here.
Keywords: expression; inflammatory; a1at may; syncytialization ... See more keywords