PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45647-8
Abstract: Proper placental development in early pregnancy ensures a positive outcome later on. The developmental relationship between the placenta and embryonic organs, such as the heart, is crucial for a normal pregnancy. However, the mechanism through… read more here.
Keywords: cardiovascular development; regulates trophoblast; trophoblast syncytialization; pibf1 regulates ... See more keywords
Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad109
Abstract: Endogenous retroviruses (ERVs) have been proposed as a driving force for the evolution of the mammalian placenta, however, the contribution of ERVs to placental development and the underlying regulatory mechanism remain largely elusive. A key… read more here.
Keywords: trophoblast syncytialization; human trophoblast; derived enhancers; placental development ... See more keywords
Elevated levels of KLF12 impair trophoblast syncytialization via GCM1 downregulation
Sign Up to like & getrecommendations! Published in 2024 at "Reproductive and Developmental Medicine"
DOI: 10.1097/rd9.0000000000000099
Abstract: Objective: Placental dysfunction is a major contributor to miscarriages in humans. We observed elevated expression of Kruppel-like factor 12 (KLF12) in placental villi of women who experienced miscarriage compared to that in women with healthy… read more here.
Keywords: trophoblast syncytialization; levels klf12; elevated levels; syncytialization ... See more keywords
S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.860261
Abstract: Recurrent pregnancy loss (RPL) is a severe complication of pregnancy that is caused by genetic abnormalities, immune dysfunction, aberrant cell biology, and tissue structure destruction. Among which, placental dysfunction is crucial in the pathogenetic progression… read more here.
Keywords: rpl; development; syncytialization; pregnancy ... See more keywords
Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1107182
Abstract: Placental dysfunction refers to the insufficiency of placental perfusion and chronic hypoxia during early pregnancy, which impairs placental function and causes inadequate supply of oxygen and nutrients to the fetus, affecting fetal development and health.… read more here.
Keywords: trophoblast syncytialization; growth restriction; intrauterine growth; syncytialization ... See more keywords
Alpha 1 Antitrypsin Regulates Trophoblast Syncytialization and Inflammatory Factor Expression
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23041955
Abstract: The serine protease inhibitor alpha1-antitrypsin (A1AT) may possess protective functions of impaired organs in a manner independent of its protease inhibitor activity. A1AT expression has been shown to fluctuate in patients with pregnancy-induced hypertension, which… read more here.
Keywords: expression; inflammatory; a1at may; syncytialization ... See more keywords