Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: Rational design, one-pot tricomponent synthesis, and lipophilicity determination.
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DOI: 10.1016/j.ejmech.2019.05.006
Abstract: We have designed novel tropinone-thiazole derivatives that showed high antiproliferative activity against a variety of cancer cell lines via caspase 3/7 activation mechanism. Among the derivatives, compounds 3b-3h were found to exhibit high activity against… read more here.
Keywords: activity; tropinone thiazole; thiazole derivatives; antiproliferative activity ... See more keywords