Tropisetron restores normal expression of BAD, SIRT1, SIRT3, and SIRT7 in the rat pressure overload-induced cardiac hypertrophy model.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23355
Abstract: Tropisetron exerts a protective effect against cardiac complications, particularly cardiac hypertrophy. Oxidative stress and apoptosis are the main contributors to the pathogenesis of cardiac hypertrophy. Sirtuins, a family of histone deacetylases, are connected to cellular… read more here.
Keywords: hypertrophy; sirt1 sirt3; expression; cardiac hypertrophy ... See more keywords
The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01170-5
Abstract: Tropisetron is a 5-HT3 receptor antagonist that exerts protective effect against DN. The aim of this study was to investigate the possible molecular mechanisms associated with the renoprotective effects of tropisetron in STZ-induced diabetic rats.… read more here.
Keywords: stz induced; induced diabetic; tropisetron; foxo3a ... See more keywords
The Possible Protective Effects of Ondansetron and Tropisetron on Optic Nerve Crush Injury in Rats
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DOI: 10.1055/a-1969-4600
Abstract: Abstract Background This study aimed to evaluate the potential neuroprotective effect of cyclosporine – a calcineurin inhibitor–, ondansetron, and tropisetron-5-hydroxytryptamine (serotonin) 3 receptor (5-HT3R) antagonists–, on optic nerve crush (ONC) injury in rats. Moreover, underlying… read more here.
Keywords: injury rats; tropisetron; calcineurin; ondansetron tropisetron ... See more keywords
Ameliorative effects of tropisetron on liver injury in streptozotocin-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2019.1640743
Abstract: Abstract This study aimed to evaluate the effect of tropisetron on liver injury induced by diabetes. Thirty-five male Wistar rats were assigned to five groups (n = 7): control (C), tropisetron (T), diabetic (D), diabetic + tropisetron (D + T) and… read more here.
Keywords: liver injury; ameliorative effects; tropisetron; diabetic rats ... See more keywords
Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence
Sign Up to like & getrecommendations! Published in 2020 at "Hormone Molecular Biology and Clinical Investigation"
DOI: 10.1515/hmbci-2020-0002
Abstract: Abstract Objectives There is an association between diabetes and liver disorders. Oxidative stress plays a crucial role in the pathology of hepatic abnormalities in diabetes. In this study, the effect of Tropisetron on the oxidative… read more here.
Keywords: diabetes rats; tropisetron; liver; effect tropisetron ... See more keywords