Tropism of SARS-CoV-2 for human cortical astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122236119
Abstract: Significance Neurological and neuropsychiatric symptoms occur in as many as one-third of patients with or recovering from COVID-19. To address severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neural tropism, we evaluated the vulnerability of primary… read more here.
Keywords: cortical astrocytes; infection; human cortical; tropism sars ... See more keywords
The PRRA Insert at the S1/S2 Site Modulates Cellular Tropism of SARS-CoV-2 and ACE2 Usage by the Closely Related Bat RaTG13
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.01751-20
Abstract: The four-residue insert (PRRA) at the boundary between the S1 and S2 subunits of SARS-CoV-2 has been widely recognized since day 1 for its role in SARS-CoV-2 S protein processing and activation. As this PRRA… read more here.
Keywords: prra insert; prra; tropism sars; sars cov ... See more keywords
Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
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DOI: 10.3201/eid2612.202308
Abstract: Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting… read more here.
Keywords: cov sars; differential tropism; bat; tropism sars ... See more keywords
Multiorgan and Vascular Tropism of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14030515
Abstract: Although the respiratory tract is the main target of SARS-CoV-2, other tissues and organs are permissive to the infection. In this report, we investigated this wide-spectrum tropism by studying the SARS-CoV-2 genetic intra-host variability in… read more here.
Keywords: tropism sars; sars cov; multiorgan vascular; tropism ... See more keywords