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   Articles with "tropoelastin" as a keyword



Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin.

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recommendations! Published in 2021 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c01286

Abstract: Dysfunctional elastin turnover plays a major role in the progression of atherosclerotic plaques. Failure of tropoelastin cross-linking into mature elastin leads to the accumulation of tropoelastin within the growing plaque, increasing its instability. Here we… read more here.

Keywords: atherosclerotic plaques; probe; mri; tropoelastin ... See more keywords

Tropoelastin: an in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilation

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recommendations! Published in 2019 at "Cardiovascular research"

DOI: 10.1093/cvr/cvz178

Abstract: Aims Dysfunctional matrix turnover is present at sites of abdominal aortic aneurysm (AAA) and leads to the accumulation of monomeric tropoelastin rather than cross-linked elastin. We used a gadolinium-based tropoelastin-specific magnetic resonance contrast agent (Gd-TESMA)… read more here.

Keywords: dysfunctional matrix; turnover; aortic dilation; tropoelastin ... See more keywords

Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models.

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recommendations! Published in 2025 at "Science translational medicine"

DOI: 10.1126/scitranslmed.adr6458

Abstract: Treatment of injuries to soft elastic organs is often hindered by challenging anatomical features and limitations of existing sealant materials, which may lack adequate tissue adhesion, elasticity, biocompatibility, and effective hemostatic properties. To address these… read more here.

Keywords: hemostasis; metro; modified human; tissue adhesion ... See more keywords

Tropoelastin Improves Post-Infarct Cardiac Function

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recommendations! Published in 2022 at "Circulation Research"

DOI: 10.1161/circresaha.122.321123

Abstract: Background: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocytes are replaced by a stiff collagen-rich scar. Compared to collagen, the extracellular matrix protein elastin has high elasticity and… read more here.

Keywords: versus control; scar; tropoelastin; human cardiac ... See more keywords