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   Articles with "tropolone" as a keyword



Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron.

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recommendations! Published in 2019 at "Leukemia research"

DOI: 10.1016/j.leukres.2018.12.007

Abstract: Tropolones are naturally occurring seven-membered non-benzenoid aromatic compounds that are of interest due to their cytotoxic properties. MO-OH-Nap is a novel α-substituted tropolone that induces caspase cleavage and upregulates markers associated with the unfolded protein… read more here.

Keywords: unfolded protein; protein response; multiple myeloma; myeloma cells ... See more keywords

Ring-Polymer Instanton Tunneling Splittings of Tropolone and Isotopomers using a Δ-Machine Learned CCSD(T) Potential: Theory and Experiment Shake Hands

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recommendations! Published in 2023 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.3c00769

Abstract: Tropolone, a 15-atom cyclic molecule, has received much interest both experimentally and theoretically due to its H-transfer tunneling dynamics. An accurate theoretical description is challenging owing to the need to develop a high-level potential energy… read more here.

Keywords: using machine; ring polymer; tropolone; polymer instanton ... See more keywords

Three Dy(iii) single-ion magnets bearing the tropolone ligand: structure, magnetic properties and theoretical elucidation.

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recommendations! Published in 2019 at "Dalton transactions"

DOI: 10.1039/c9dt00364a

Abstract: The reactions of dysprosium nitrate with the main ligand of tropolone (HL) in the presence of ancillary ligands of phenanthroline (phen) or 1,3,5-benzenetricarboxylic acid (H3BTC) gave three mononuclear complexes, [Dy(phen)2(L)(NO3)2] (1), [Dy(phen)(L)3]·H2O (2) and [Dy(H3BTC)(H2O)(L)3]2·3H2O… read more here.

Keywords: single ion; ion magnets; magnetic properties; ion ... See more keywords

Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs

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recommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"

DOI: 10.1080/14756366.2022.2028782

Abstract: Abstract The influence of base type, temperature, and solvent on regioselective C(9)/C(10) “click” modifications within the tropolone ring of colchiceine (2) is investigated. New ether derivatives of 2, bearing alkyne, azide, vinyl, or halide aryl… read more here.

Keywords: colchiceine; regioselective approach; tropolone ring; hybrid derivatives ... See more keywords

Antitumor efficacy of 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone in lung cancer xenografts.

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recommendations! Published in 2021 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2021.39.15_suppl.e15008

Abstract: e15008 Background: Lung cancer is the most common cancer worldwide. The efficacy of chemotherapy for this tumor does not exceed 40%. Moreover, all cytotoxic agents cause many side effects. The search for new substances with… read more here.

Keywords: lung cancer; cancer; tropolone; nitro chloroquinoline ... See more keywords