Stabilizing photo-sensitive colchicine through rebalancing electron distribution of the reactive tropolone ring
Sign Up to like & getrecommendations! Published in 2021 at "CrystEngComm"
DOI: 10.1039/d0ce01551b
Abstract: Colchicine is light-sensitive and undergoes electrocyclic reaction upon exposure to light. In this study, the photostability of colchicine was found to be significantly improved via rebalancing the electron density of the tropolone ring system after… read more here.
Keywords: photo sensitive; stabilizing photo; colchicine; rebalancing electron ... See more keywords
Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2028782
Abstract: Abstract The influence of base type, temperature, and solvent on regioselective C(9)/C(10) “click” modifications within the tropolone ring of colchiceine (2) is investigated. New ether derivatives of 2, bearing alkyne, azide, vinyl, or halide aryl… read more here.
Keywords: colchiceine; regioselective approach; tropolone ring; hybrid derivatives ... See more keywords