Design, synthesis, and biological evaluation of aminopyridine derivatives as novel tropomyosin receptor kinase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200438
Abstract: Tropomyosin receptor kinase (TRK) is a successful target for the treatment of various cancers caused by NTRK gene fusions. Herein, based on a rational drug design strategy, we designed and synthesized 35 aminopyrimidine derivatives that… read more here.
Keywords: tropomyosin receptor; evaluation; receptor kinase; showed compound ... See more keywords
Spotlight on the treatment of infantile fibrosarcoma in the era of neurotrophic tropomyosin receptor kinase inhibitors: International consensus and remaining controversies.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.06.028
Abstract: Targeted neurotrophic tropomyosin receptor kinase (TRK) inhibitors offer a highly specific therapeutic option for patients with infantile fibrosarcoma (IFS) carrying the NTRK gene translocation. International recommendations are needed to define the role of TRK inhibitors… read more here.
Keywords: chemotherapy; neurotrophic tropomyosin; receptor kinase; consensus ... See more keywords
Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.06.064
Abstract: A series of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides was designed and synthesized as new tropomyosin receptor kinases (Trks) inhibitors by utilizing a structure-guided optimization strategy. One of the most potent compounds 9o suppressed TrkA/B/C with IC50 values of 2.65,… read more here.
Keywords: pyrazin ylethynyl; imidazo pyrazin; tropomyosin receptor; ylethynyl methylbenzamides ... See more keywords
Primary sensory neurons expressing tropomyosin receptor kinase A in the rat trigeminal ganglion
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.10.009
Abstract: Tropomyosin receptor kinase A (trkA), a high affinity receptor for nerve growth factor (NGF), has been implicated in neuronal survival, neurite outgrowth and inflammatory pain. So far, the characterization of the primary sensory neurons that… read more here.
Keywords: receptor kinase; tropomyosin receptor; sensory neurons; receptor ... See more keywords
Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01092
Abstract: The use of kinase-directed precision medicine has been heavily pursued since the discovery and development of imatinib. Annually, it is estimated that around ∼20 000 new cases of tropomyosin receptor kinase (TRK) cancers are diagnosed, with… read more here.
Keywords: medicine; trk inhibitors; kinase; tropomyosin receptor ... See more keywords
Sexual Motivation in Male Rats is Modulated by Tropomyosin Receptor Kinase B (TrkB)
Sign Up to like & getrecommendations! Published in 2019 at "Behavioral Neuroscience"
DOI: 10.1037/bne0000286
Abstract: The expression of brain derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) are regulated by gonadal hormone signaling and are expressed in brain areas that are important for sexual behaviors. Accordingly, BDNF and… read more here.
Keywords: male rats; sexual motivation; motivation; tropomyosin receptor ... See more keywords
Tropomyosin-receptor kinase fused gene (TFG) regulates lipid production in human sebocytes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43209-3
Abstract: The endoplasmic reticulum (ER) is an organelle in which important cellular events such as protein synthesis and lipid production occur. Although many lipid molecules are produced in the ER, the effect of ER-organizing proteins on… read more here.
Keywords: receptor kinase; production; lipid production; tfg ... See more keywords
A tropomyosin-receptor kinase-fused gene mutation associates with vacuolar myopathy
Sign Up to like & getrecommendations! Published in 2018 at "Neurology: Genetics"
DOI: 10.1212/nxg.0000000000000287
Abstract: A 44-year-old Caucasian man presented with a 7-year history of upper and lower limb muscle fasciculations and cramps, progressive asymmetric weakness, muscle atrophy, and length-dependent sensory loss. His parents (deceased), 3 older siblings, and 3… read more here.
Keywords: receptor kinase; muscle; weakness; tropomyosin receptor ... See more keywords