Initial trough concentration may be beneficial in preventing linezolid-induced thrombocytopenia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2022.2043538
Abstract: Abstract We assessed whether prospective therapeutic drug monitoring to optimise the therapeutic range could prevent linezolid-induced thrombocytopenia. This prospective interventional study was conducted from September 2017 to October 2020 among 37 adult patients receiving linezolid.… read more here.
Keywords: linezolid induced; therapeutic range; range; induced thrombocytopenia ... See more keywords
869: VANCOMYCIN TROUGHS CAN PREDICT AUC/MIC RATIOS OF 400-600 IN CRITICALLY ILL PATIENTS
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000631612.17905.d2
Abstract: Introduction/Hypothesis: The efficacy of vancomycin has historically been associated with a defined trough concentration range. Accumulating evidence indicates vancomycin efficacy is more strongly associated with the achievement of a 24 hour area under the curve/minimum… read more here.
Keywords: mic ratio; 400 600; auc24 mic; trough concentration ... See more keywords
A systematic review and meta‐analysis of dabigatran peak and trough concentration in adults
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15431
Abstract: Dabigatran etexilate is an oral direct thrombin inhibitor used in preventing thromboembolism in patients with atrial fibrillation and several other conditions. Routine dabigatran concentration monitoring is not recommended in clinical practice; however, measurement of dabigatran… read more here.
Keywords: dabigatran; concentration; dabigatran concentrations; peak trough ... See more keywords
Plasma trough concentration distribution and safety of high‐dose teicoplanin for patients with augmented renal clearance
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13700
Abstract: There are few reports on the distribution of the plasma trough concentration (Cmin) of teicoplanin in patients with augmented renal clearance (ARC) and on the safety of a high‐dose regimen (HD; 800 mg loading dose for… read more here.
Keywords: plasma trough; patients augmented; teicoplanin patients; renal clearance ... See more keywords
Tacrolimus Dose Optimization Strategy for Refractory Ulcerative Colitis Based on the Cytochrome P450 3A5 Polymorphism Prediction Using Trough Concentration after 24 Hours
Sign Up to like & getrecommendations! Published in 2018 at "Digestion"
DOI: 10.1159/000484227
Abstract: Background: In the tacrolimus treatment for refractory ulcerative colitis (UC), dose adjustment is necessary because the required doses to keep appropriate drug concentrations are significantly different among individuals. Cytochrome P450 (CYP) 3A5 polymorphism affects tacrolimus… read more here.
Keywords: optimization strategy; cyp3a5 polymorphism; trough concentration; dose optimization ... See more keywords
Remission of hepatotoxicity in chronic pulmonary aspergillosis patients after lowering trough concentration of voriconazole
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v8.i20.4700
Abstract: BACKGROUND Chronic pulmonary aspergillosis (CPA) is a rare syndrome that is often accompanied by gradual lung tissue destruction. Voriconazole is usually employed as the first-line agent for CPA treatment. However, some patients can develop hepatotoxicity… read more here.
Keywords: lowering trough; treatment; trough concentration; hepatotoxicity ... See more keywords
Hyperlipidemia Caused by Voriconazole: A Case Report
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DOI: 10.2147/idr.s301198
Abstract: Abstract Voriconazole has been widely used in clinical practice for nearly 20 years. The adverse reactions caused by voriconazole have been reported gradually, such as visual impairment, hepatotoxicity, skin rash. At present, there are few… read more here.
Keywords: case; cholesterol; caused voriconazole; voriconazole case ... See more keywords
Linezolid-Associated Neuropathy in Patients with MDR/XDR Tuberculosis in Shenzhen, China
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DOI: 10.2147/idr.s365371
Abstract: Objective Linezolid is one of the key drugs for the treatment of multidrug-resistant/extensively drug-resistant tuberculosis (MDR/XDR-TB). We aimed to describe the incorporation of the Michigan Neuropathy Screening Instrument (MNSI) and serum trough concentration as screening… read more here.
Keywords: neuropathy patients; tuberculosis; mdr xdr; serum trough ... See more keywords
Impact of Initial Vancomycin Trough Concentration on Clinical and Microbiological Outcomes of Methicillin-Resistant Staphylococcus aureus Bacteremia in Children
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DOI: 10.3346/jkms.2017.32.1.22
Abstract: It is important to use vancomycin in a proper manner to ensure optimal drug exposure. Despite extensive use of vancomycin in children, studies on its optimal trough concentration (Ctrough) in the pediatric population remained rare.… read more here.
Keywords: vancomycin; resistant staphylococcus; trough concentration; bacteremia ... See more keywords
The CSF Vancomycin Concentration in Patients With Post-operative Intracranial Infection Can Be Predicted by the WBCs to Total Cells Ratio and the Serum Trough Concentration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.893089
Abstract: Background The pharmacokinetics of vancomycin in cerebrospinal fluid (CSF) is an important basis for evaluating the bactericidal effect. The accuracy of using serum vancomycin concentrations only to estimate the CSF concentrations remains controversial, may lead… read more here.
Keywords: wbcs total; csf; intracranial infection; concentration ... See more keywords
Clinical Application Value of Pharmacokinetic Parameters of Vancomycin in Children Treated in the Pediatric Intensive Care Unit
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.867712
Abstract: Objective To explore the efficacy and safety of vancomycin as measured by pharmacokinetic/pharmacodynamic parameters in children with severe infection in the Pediatric Intensive Care Unit (PICU) and to determine the appropriate threshold for avoiding nephrotoxicity.… read more here.
Keywords: vancomycin related; pediatric intensive; related nephrotoxicity; concentration ... See more keywords