Lateral flow test versus enzyme‐linked immunosorbent assay to measure infliximab trough concentrations: A head‐to‐head comparison
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Pediatric Gastroenterology and Nutrition"
DOI: 10.1002/jpn3.12372
Abstract: Abstract Objectives Infliximab is an antitumour necrosis factor agent used to treat inflammatory bowel disease (IBD). Measurement of infliximab trough concentrations (C‐troughs) are used to optimize drug exposure and improve outcomes. Currently, enzyme‐linked immunosorbent assays… read more here.
Keywords: infliximab trough; lateral flow; enzyme linked; trough concentrations ... See more keywords
A joint model of longitudinal pharmacokinetic and time-to-event data to study exposure–response relationships: a proof-of-concept study with alectinib
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-024-04698-w
Abstract: In exposure–response analyses of oral targeted anticancer agents, longitudinal plasma trough concentrations are often aggregated into a single value even though plasma trough concentrations can vary over time due to dose adaptations, for example. The… read more here.
Keywords: time; exposure response; response; trough concentrations ... See more keywords
Optimizing vancomycin dosing in pediatrics: a machine learning approach to predict trough concentrations in children under four years of age
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-024-01745-7
Abstract: Vancomycin trough concentration is closely associated with clinical efficacy and toxicity. Predicting vancomycin trough concentrations in pediatric patients is challenging due to significant inter-individual variability and rapid physiological changes during maturation. This study aimed to… read more here.
Keywords: machine learning; vancomycin trough; years age; trough concentrations ... See more keywords
Comparison of Ustekinumab Trough Concentrations Measured by 2 ELISA Kits and Evaluation of Clinical Response in Crohn’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000976
Abstract: Supplemental Digital Content is Available in the Text. Background: Ustekinumab is a recently introduced biological agent for the treatment of Crohn’s disease. The clinical use of the trough concentration of ustekinumab is not as standardized… read more here.
Keywords: trough concentrations; elisa kits; concentrations measured; crohn disease ... See more keywords
Effect of Carbamazepine on Darunavir Trough Concentrations: When the Dose Can Make the Difference—A Case Study
Sign Up to like & getrecommendations! Published in 2024 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000001179
Abstract: Background: Carbamazepine (CBZ) is an antiseizure medication known to induce the expression of cytochrome P4503A metabolic enzymes. Here, we describe a man living with HIV who underwent several changes in the daily dose of CBZ,… read more here.
Keywords: carbamazepine; darunavir trough; cbz; drug ... See more keywords
Intraindividual and Interindividual Variability of Olanzapine Trough Concentrations in Patients Treated With the Long-Acting Injectable Formulation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000000913
Abstract: Background A long-acting injectable (LAI) formulation of olanzapine has been developed as an alternative to oral regimens. A therapeutic range of 20 to 80 ng/mL for oral olanzapine trough concentrations has been proposed. Here, we… read more here.
Keywords: intraindividual interindividual; variability olanzapine; trough concentrations; formulation ... See more keywords
Relationship between Ustekinumab trough concentrations and clinical, biochemical and endoscopic outcomes in Crohn’s disease: A multi-center nationwide retrospective study (TARGET STUDY)
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DOI: 10.1097/md.0000000000038804
Abstract: Ustekinumab has been shown to be effective in inducing and maintain clinical and endoscopic remission in Crohn disease (CD). We aim to assess whether ustekinumab trough levels are associated with improved outcomes in CD in… read more here.
Keywords: clinical biochemical; trough concentrations; endoscopic; study ... See more keywords
Elevated posaconazole trough concentrations are not associated with increased risk for posaconazole toxicity in lung transplant recipients
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Transplantation"
DOI: 10.1111/ctr.14826
Abstract: Posaconazole is used for prophylaxis and treatment of invasive fungal infections in lung transplant recipients (LTR). Previous studies have not described the relationship between elevated posaconazole trough concentrations and adverse drug reactions in this population. read more here.
Keywords: transplant recipients; lung transplant; elevated posaconazole; trough concentrations ... See more keywords
Therapeutic Drug Monitoring of Voriconazole in Children from a Tertiary Care Center in China
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DOI: 10.1128/aac.00955-18
Abstract: Voriconazole is a broad-spectrum triazole antifungal and the first-line treatment for invasive aspergillosis (IA). The aim of this research was to study the dose adjustments of voriconazole as well as the affecting factors influencing voriconazole… read more here.
Keywords: voriconazole trough; therapeutic drug; drug monitoring; trough concentrations ... See more keywords
Impact of Real-Time Therapeutic Drug Monitoring on the Prescription of Antibiotics in Burn Patients Requiring Admission to the Intensive Care Unit
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DOI: 10.1128/aac.01818-17
Abstract: ABSTRACT As pharmacokinetics after burn trauma are difficult to predict, we conducted a 3-year prospective, monocentric, randomized, controlled trial to determine the extent of under- and overdosing of antibiotics and further evaluate the impact of… read more here.
Keywords: real time; trough concentrations; time; therapeutic drug ... See more keywords
Are Vancomycin Trough Concentrations of 15 to 20 mg/L Associated With Increased Attainment of an AUC/MIC ≥ 400 in Patients With Presumed MRSA Infection?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacy Practice"
DOI: 10.1177/0897190016642692
Abstract: Purpose: To determine whether there is an association between higher vancomycin trough concentrations and attainment of a calculated area under the concentration–time curve (AUC)/minimum inhibitory concentration (MIC) ≥400. Methods: A retrospective analysis was conducted among… read more here.
Keywords: vancomycin trough; auc mic; trough concentrations; mic 400 ... See more keywords