Comparison of Ustekinumab Trough Concentrations Measured by 2 ELISA Kits and Evaluation of Clinical Response in Crohn’s Disease
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DOI: 10.1097/ftd.0000000000000976
Abstract: Supplemental Digital Content is Available in the Text. Background: Ustekinumab is a recently introduced biological agent for the treatment of Crohn’s disease. The clinical use of the trough concentration of ustekinumab is not as standardized… read more here.
Keywords: trough concentrations; elisa kits; concentrations measured; crohn disease ... See more keywords
Intraindividual and Interindividual Variability of Olanzapine Trough Concentrations in Patients Treated With the Long-Acting Injectable Formulation
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DOI: 10.1097/jcp.0000000000000913
Abstract: Background A long-acting injectable (LAI) formulation of olanzapine has been developed as an alternative to oral regimens. A therapeutic range of 20 to 80 ng/mL for oral olanzapine trough concentrations has been proposed. Here, we… read more here.
Keywords: intraindividual interindividual; variability olanzapine; trough concentrations; formulation ... See more keywords
Elevated posaconazole trough concentrations are not associated with increased risk for posaconazole toxicity in lung transplant recipients
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DOI: 10.1111/ctr.14826
Abstract: Posaconazole is used for prophylaxis and treatment of invasive fungal infections in lung transplant recipients (LTR). Previous studies have not described the relationship between elevated posaconazole trough concentrations and adverse drug reactions in this population. read more here.
Keywords: transplant recipients; lung transplant; elevated posaconazole; trough concentrations ... See more keywords
Therapeutic Drug Monitoring of Voriconazole in Children from a Tertiary Care Center in China
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DOI: 10.1128/aac.00955-18
Abstract: Voriconazole is a broad-spectrum triazole antifungal and the first-line treatment for invasive aspergillosis (IA). The aim of this research was to study the dose adjustments of voriconazole as well as the affecting factors influencing voriconazole… read more here.
Keywords: voriconazole trough; therapeutic drug; drug monitoring; trough concentrations ... See more keywords
Impact of Real-Time Therapeutic Drug Monitoring on the Prescription of Antibiotics in Burn Patients Requiring Admission to the Intensive Care Unit
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DOI: 10.1128/aac.01818-17
Abstract: ABSTRACT As pharmacokinetics after burn trauma are difficult to predict, we conducted a 3-year prospective, monocentric, randomized, controlled trial to determine the extent of under- and overdosing of antibiotics and further evaluate the impact of… read more here.
Keywords: real time; trough concentrations; time; therapeutic drug ... See more keywords
Are Vancomycin Trough Concentrations of 15 to 20 mg/L Associated With Increased Attainment of an AUC/MIC ≥ 400 in Patients With Presumed MRSA Infection?
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DOI: 10.1177/0897190016642692
Abstract: Purpose: To determine whether there is an association between higher vancomycin trough concentrations and attainment of a calculated area under the concentration–time curve (AUC)/minimum inhibitory concentration (MIC) ≥400. Methods: A retrospective analysis was conducted among… read more here.
Keywords: vancomycin trough; auc mic; trough concentrations; mic 400 ... See more keywords
Impact of UGT1A1 gene polymorphisms on plasma dolutegravir trough concentrations and neuropsychiatric adverse events in Japanese individuals infected with HIV-1
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DOI: 10.1186/s12879-017-2717-x
Abstract: BackgroundDolutegravir (DTG) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1), and partly by cytochrome P450 3A (CYP3A). Therefore, we focused on UGT1A1 gene polymorphisms (*6 and *28) in Japanese individuals infected with human immunodeficiency… read more here.
Keywords: dtg; gene polymorphisms; trough concentrations; dtg trough ... See more keywords
Risk factors for decreased teicoplanin trough concentrations during initial dosing in critically ill patients.
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DOI: 10.1619/ph.2019.8731
Abstract: Aim of the study: Here, we investigated the risk factors for decreased teicoplanin plasma trough concentrations relative to the initial dosing in critically ill patients. Patients and methods: Data obtained from 80 eligible critically ill… read more here.
Keywords: risk; trough concentrations; initial dosing; risk factors ... See more keywords
Predictors of Voriconazole Trough Concentrations in Patients with Child–Pugh Class C Cirrhosis: A Prospective Study
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DOI: 10.3390/antibiotics10091130
Abstract: This prospective observational study aimed to clinically describe voriconazole administrations and trough concentrations in patients with Child–Pugh class C and to investigate the variability of trough concentration. A total of 144 voriconazole trough concentrations from… read more here.
Keywords: trough concentrations; patients child; concentrations patients; child pugh ... See more keywords
Evaluation of Dosing Guidelines for Gentamicin in Neonates and Children
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DOI: 10.3390/antibiotics12050810
Abstract: Although aminoglycosides are frequently prescribed to neonates and children, the ability to reach effective and safe target concentrations with the currently used dosing regimens remains unclear. This study aims to evaluate the target attainment of… read more here.
Keywords: gentamicin neonates; evaluation dosing; trough concentrations; neonates children ... See more keywords