Infliximab Trough Levels Are Not Predictive of Relapse in Patients with IBD in Endoscopic Remission: A Multicenter Cohort Study
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06645-0
Abstract: Therapeutic drug monitoring (TDM) is important in optimizing use of biologics in inflammatory bowel diseases (IBD). However, the role of proactive TDM during remission remains uncertain. This retrospective study included patients receiving infliximab (IFX) therapy… read more here.
Keywords: trough levels; remission; study; relapse ... See more keywords
Correlations Among Subcutaneous Immunoglobulin Dosage, Immunoglobulin G Serum Pre-infusional Levels and Body Mass Index in Primary Antibody Deficiency Patients: A Pooled Analysis from the SHIFT/IBIS Studies
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Drug Investigation"
DOI: 10.1007/s40261-020-00885-8
Abstract: Background and Objective In recent years, two Italian non-interventional studies evaluated subcutaneous immunoglobulin (SCIG) treatment in patients affected by primary antibody deficiency (PAD). The SHIFT study considered patients who were treated with intravenous immunoglobulin (IVIG) or… read more here.
Keywords: trough levels; subcutaneous immunoglobulin; immunoglobulin; igg trough ... See more keywords
MON-020 MULTIPLE POTENTIAL AETIOLOGIES OF MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS IN A COMPLEX PATIENT
Sign Up to like & getrecommendations! Published in 2019 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2019.05.806
Abstract: Methods: Patients with NS onset between age 1-60 years and diagnosed with SRNS between January 2010 and October 2015 (n=76) were included. All patients underwent renal biopsy and were started on either cyclosporine (CsA) at… read more here.
Keywords: trough levels; histology; age; patients received ... See more keywords
Trough Levels of Everolimus Are Associated With Recurrence Rates of Hepatocellular Carcinoma After Liver Transplantation.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.01.069
Abstract: PURPOSE Everolimus, a mammalian target of rapamycin inhibitor, may have a protective role on hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT), but data regarding the impact of its trough serum levels on HCC recurrence… read more here.
Keywords: hepatocellular carcinoma; trough levels; levels everolimus; recurrence ... See more keywords
Cannabidiol Interacts Significantly with Everolimus-Report of a Patient with Tuberous Sclerosis Complex.
Sign Up to like & getrecommendations! Published in 2019 at "Neuropediatrics"
DOI: 10.1055/s-0039-1695786
Abstract: A 6.5-year-old female patient with a TSC2 mutation had been given everolimus (EVE) for 3 years for pharmacoresistant focal epilepsy and for life-threatening, severe ventricular dysrhythmia. EVE had been started with daily dose of 0.15 mg/kg/day and… read more here.
Keywords: trough levels; cannabidiol interacts; cbd; blood trough ... See more keywords
Success and safety of high infliximab trough levels in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2018.1486882
Abstract: Abstract Objective: A prospective trial suggests target infliximab trough levels of 3–7 μg/mL, yet data on additional therapeutic benefits and safety of higher trough levels are scarce. Aim: To explore whether high infliximab trough levels (≥7 μg/mL)… read more here.
Keywords: trough levels; high trough; high infliximab; disease ... See more keywords
Influence of cerebrospinal fluid drainage and other variables on the plasma vancomycin trough levels in postoperative neurosurgical patients
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Neurosurgery"
DOI: 10.1080/02688697.2020.1769023
Abstract: Abstract Background Therapeutic drug monitoring (TDM) aims to minimise the clinical impact of vancomycin (VCM) pharmacokinetic variability. However, TDM data are limited among specific patient populations, including postoperative neurosurgical populations. The objective of this study… read more here.
Keywords: trough levels; postoperative neurosurgical; group; drainage ... See more keywords
P295 Comparative Assessment of Infliximab Trough Levels between Point-of-Care Testing and current Standard of Care (enzyme linked immunosorbent assay) in patients with Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.419
Abstract: Infliximab (IFX) is a monoclonal antibody that targets cytokine tumor necrosis factor; it is used for the treatment of patients with active inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). IFX… read more here.
Keywords: care; inflammatory bowel; trough levels; ifx ... See more keywords
Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjy155
Abstract: Background and Aims Mucosal healing is an important treatment goal in Crohn's disease. We investigated the association between serum infliximab trough levels and mucosal healing, and the infliximab cut-off levels required for mucosal healing in… read more here.
Keywords: infliximab trough; trough levels; mucosal healing; crohn disease ... See more keywords
Swapping Versus Dose Optimization in Patients Losing Response to Adalimumab With Adequate Drug Levels.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izab158
Abstract: BACKGROUND In cases of loss of response due to mechanistic failure under antitumor necrosis factor agents, it is recommended to switch to another class of biologics. Two different strategies were compared in patients with inflammatory… read more here.
Keywords: trough levels; response; loss response; group ... See more keywords
Infliximab Trough Levels Are Associated With Transmural Sonographic Healing in Inflammatory Bowel Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izac186
Abstract: BACKGROUND Mucosal healing improves clinical outcomes in patients with inflammatory bowel disease (IBD) and is associated with higher infliximab trough levels (ITLs). Transmural healing, assessed by intestinal ultrasound (IUS), is emerging as an objective target… read more here.
Keywords: trough levels; disease; itl; inflammatory bowel ... See more keywords