Troxerutin exerts neuroprotection in 6‐hydroxydopamine lesion rat model of Parkinson’s disease: Possible involvement of PI3K/ER&bgr; signaling
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.03.002
Abstract: ABSTRACT Parkinson's disease (PD) is a neurodegenerative disease with progressive loss of mesencephalic dopaminergic neurons of the substantia nigra and with multiple incapacitating motor and non‐motor symptoms. Troxerutin is a natural bioflavonoid with nephro‐ and… read more here.
Keywords: troxerutin; rat model; bgr; disease ... See more keywords
The bioflavonoid troxerutin prevents gestational hypertension in mice by inhibiting STAT3 signaling
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension Research"
DOI: 10.1038/s41440-020-00568-z
Abstract: Gestational hypertension is a high-risk disease for women, and the current treatments have limited efficacies. Here, we aimed to evaluate troxerutin, which is a natural monomer of flavone, in the treatment of gestational hypertension. Pregnant… read more here.
Keywords: troxerutin; expression; mice; hypertension ... See more keywords
Troxerutin-Mediated Complement Pathway Inhibition is a Disease-Modifying Treatment for Inflammatory Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.845457
Abstract: Troxerutin (TXR) is a phytochemical reported to possess anti-inflammatory and hepatoprotective effects. In this study, we aimed to exploit the antiarthritic properties of TXR using an adjuvant-induced arthritic (AIA) rat model. AIA-induced rats showed the… read more here.
Keywords: disease; troxerutin mediated; mediated complement; complement pathway ... See more keywords
Troxerutin Stimulates Osteoblast Differentiation of Mesenchymal Stem Cell and Facilitates Bone Fracture Healing
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.723145
Abstract: Troxerutin (TRX), a semi-synthetic derivative of the natural bioflavonoid rutin, is a bioactive flavonoid widely abundant in various fruits and vegetables. Known as vitamin P4, TRX has been demonstrated to have several activities including anti-inflammation,… read more here.
Keywords: bone fracture; fracture; troxerutin; trx ... See more keywords