Impact of lipid rafts on transient receptor potential channel activities
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30679
Abstract: Members of the transient receptor potential (TRP) superfamily are cation channels that are expressed in nearly every mammalian cell type and respond as cellular sensors to various environmental stimuli. Light, pressure, osmolarity, temperature, and other… read more here.
Keywords: transient receptor; lipid rafts; receptor potential; trp channel ... See more keywords
In Silico Approaches for TRP Channel Modulation.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9446-5_12
Abstract: The implication of several TRP ion channels (e.g., TRPV1) in diverse physiological and pathological processes has signaled them as pivotal drug targets. Consequently, the identification of selective and potent ligands for these channels is of… read more here.
Keywords: channel modulation; trp channel; pharmacology; silico approaches ... See more keywords
TRP Channel Classification.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-94-024-1088-4_1
Abstract: The transient receptor potential (TRP) ion channels are named after the discovery of the photo-transducted channels in Drosophila. TRPs, activated by various extracellular and intracellular stimuli, play a plethora of physiological and pathological roles. There… read more here.
Keywords: classification; trp channel; trp; biology ... See more keywords
The S4---S5 linker - gearbox of TRP channel gating.
Sign Up to like & getrecommendations! Published in 2017 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.04.002
Abstract: Transient receptor potential (TRP) channels are cation channels which participate in a wide variety of physiological processes in organisms ranging from fungi to humans. They fulfill roles in body homeostasis, are sensors for noxious chemicals… read more here.
Keywords: linker gearbox; trp channel; trp; channel ... See more keywords
A genetic TRP down the channel to praziquantel resistance.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in parasitology"
DOI: 10.1016/j.pt.2022.02.006
Abstract: The anthelmintic praziquantel (PZQ) is an essential tool in controlling schistosomiasis, so reports of reduced PZQ efficacy are of great public health concern. Le Clec'h et al. recently identified a gene responsible for PZQ resistance… read more here.
Keywords: praziquantel resistance; resistance; trp channel; genetic trp ... See more keywords
Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04828-y
Abstract: Transient receptor potential (TRP) channels are involved in various physiological processes, including sensory transduction. The TRP channel TRPV6 mediates calcium uptake in epithelia and its expression is dramatically increased in numerous types of cancer. TRPV6… read more here.
Keywords: trp channels; trp channel; trpv6; allosteric modulation ... See more keywords
Primary cilia TRP channel regulates hippocampal excitability
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2219686120
Abstract: Significance Primary cilia are antenna-like organelles that represent a frontier of knowledge in neuroscience research. They were first reported by Duncan and Dahl more than 60 years ago, and although they are implicated in neurodevelopmental… read more here.
Keywords: trp channel; channel regulates; excitability; regulates hippocampal ... See more keywords
Identification of molecular subtypes and prognostic signatures based on transient receptor potential channel-related genes to predict the prognostic risk of hepatocellular carcinoma: A review
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033228
Abstract: Abnormal transient receptor potential (TRP) channel function interferes with intracellular calcium-based signaling and causes malignant phenotypes. However, the effects of TRP channel-related genes on hepatocellular carcinoma (HCC) remain unclear. This study aimed to identify HCC… read more here.
Keywords: molecular subtypes; trp channel; channel related; risk ... See more keywords
Sensory TRP Channels in Three Dimensions.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-032620-105738
Abstract: Transient receptor potential (TRP) ion channels are sophisticated signaling machines that detect a wide variety of environmental and physiological signals. Every cell in the body expresses one or more members of the extended TRP channel… read more here.
Keywords: sensory trp; trp channel; trp channels; biochemistry ... See more keywords
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280448
Abstract: Transient receptor potential (TRP) channels are activated by various extracellular and intracellular stimuli and are involved in many physiological events. Because compounds that act on TRP channels are potential candidates for therapeutic agents, a simple… read more here.
Keywords: activation; ectodomain shedding; trp channel; trp channels ... See more keywords
Comprehensive Analysis of TRP Channel–Related Genes in Patients With Triple-Negative Breast Cancer for Guiding Prognostic Prediction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.941283
Abstract: Background Triple-negative breast cancer (TNBC) is a special subtype of breast cancer. Transient Receptor Potential (TRP) channel superfamily has emerged as a novel and interesting target in a variety of tumors. However, the association of… read more here.
Keywords: trp channel; channel related; risk group; analysis ... See more keywords