Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival
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DOI: 10.1128/iai.00290-17
Abstract: ABSTRACT Ehrlichia chaffeensis secretes tandem repeat protein (TRP) effectors that are involved in a diverse array of host cell interactions, some of which directly activate cell signaling pathways and reprogram host gene transcription to promote… read more here.
Keywords: protein; chaffeensis; trp120; host ... See more keywords
Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes
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DOI: 10.1128/mbio.00076-22
Abstract: E. chaffeensis infects and replicates in mononuclear phagocytes, but how it evades innate immune defenses of this indispensable primary innate immune cell is not well understood. This investigation revealed the molecular details of a ligand… read more here.
Keywords: chaffeensis; notch signaling; cell; trp120 ... See more keywords