The Pathogenesis of Therapy-Related Myeloid Neoplasms from TP53-Mutant Clonal Hematopoiesis
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-205209
Abstract: Introduction Therapy-related myeloid neoplasms (t-MN) arise from pre-malignant hematopoietic stem and progenitor cells (HSPCs) carrying mutations in leukemia driver genes. Patient outcomes are dismal, especially when harboring mutations in TP53. The molecular mechanisms underlying the… read more here.
Keywords: tp53 mutant; trp53 mutations; therapy; mono biallelic ... See more keywords