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   Articles with "trpa1" as a keyword



Chemical and thermal sensitivity of medaka TRPA1 analyzed in heterologous expression system.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.10.057

Abstract: TRPA1 of insects and several tetrapod vertebrates except for those of rodents have been reported to be activated by noxious chemicals and also by high temperature with a relatively clear threshold. We previously analyzed the… read more here.

Keywords: trpa1; medaka; chemical thermal; heat ... See more keywords
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TRPA1 is selected as a semi-conserved channel during vertebrate evolution due to its involvement in spermatogenesis.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.02.121

Abstract: TRPA1 is a non-selective cation channel originated in invertebrates. The genomic locus containing TRPA1 gene remains highly conserved and retained in all vertebrates. TRPA1 gene is evolutionarily selected, yet maintained as a highly diverged protein.… read more here.

Keywords: semi conserved; trpa1; selected semi; vertebrate evolution ... See more keywords

Enhanced Sensory Coding in Mouse Vibrissal and Visual Cortex through TRPA1.

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.107935

Abstract: Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel, broadly expressed throughout the body. Despite its expression in the mammalian brain, little is known about the contribution of TRPA1 to cortical function. Here,… read more here.

Keywords: enhanced sensory; trpa1; cortex; vibrissal ... See more keywords
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The neuro-immune interaction in airway inflammation through TRPA1 expression in CD4+ T cells of asthmatic mice.

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recommendations! Published in 2020 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2020.106696

Abstract: Asthma is an inflammatory disorder of the airways dominated by a Th2-type pattern. Recently, an emerging interest arises whether transient receptor potential ankyrin 1 (TRPA1) plays a potential role in the adaptive immune response. In… read more here.

Keywords: cd4 cells; trpa1; asthmatic mice; expression ... See more keywords
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Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel

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recommendations! Published in 2020 at "Neuron"

DOI: 10.1016/j.neuron.2019.11.023

Abstract: Transient receptor potential channel subfamily A member 1 (TRPA1) is a Ca2+-permeable cation channel that serves as one of the primary sensors of environmental irritants and noxious substances. Many TRPA1 agonists are electrophiles that are… read more here.

Keywords: insights electrophile; trpa1; structural insights; channel ... See more keywords

Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein

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recommendations! Published in 2017 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2016.08.028

Abstract: ABSTRACT Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke‐induced lung injury, we… read more here.

Keywords: high level; trpa1; level acrolein; mice ... See more keywords

Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.

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recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.3c02121

Abstract: Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium ion channel highly expressed in the primary sensory neurons, functioning as a polymodal sensor for exogenous and endogenous stimuli, and has been implicated in neuropathic… read more here.

Keywords: aldehyde oxidase; trpa1; gdc 6599; toxicity ... See more keywords

TRPA1 siRNA-Loaded Nanoformulation Ameliorates Chemotherapy-Induced Peripheral Neuropathy.

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recommendations! Published in 2025 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.5c00090

Abstract: Small interfering RNA (siRNA) has emerged as a cutting-edge therapeutic strategy, with significant promise for addressing peripheral neuropathies. Despite its immense revolutionary therapeutic potential, the application and sustained release of siRNA for the treatment of… read more here.

Keywords: trpa1; sirna formulation; trpa1 sirna; sirna loaded ... See more keywords

Identification of a Nonelectrophilic and Selective TRPA1 Agonist for Alleviation of Inflammatory Pain through Channel Desensitization.

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recommendations! Published in 2025 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.5c00258

Abstract: Transient receptor potential ankyrin 1 (TRPA1) agonists exert long-lasting analgesic effects by inducing neuronal desensitization, a similar strategy has been confirmed in the approval of capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist for… read more here.

Keywords: inflammatory pain; trpa1; desensitization; pain ... See more keywords

The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens

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recommendations! Published in 2024 at "Molecular Psychiatry"

DOI: 10.1038/s41380-024-02623-4

Abstract: Drug addiction therapies commonly fail because continued drug use promotes the release of excessive and pleasurable dopamine levels. Because the connection between pleasure and drug use becomes hard-wired in the nucleus accumbens (NAc), which interfaces… read more here.

Keywords: trpa1; cocaine; reward; nucleus accumbens ... See more keywords

A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-38852-9

Abstract: Current medications inadequately treat the symptoms of chronic pain experienced by over 50 million people in the United States, and may come with substantial adverse effects signifying the need to find novel treatments. One novel… read more here.

Keywords: trpa1 mediated; trpa1; screening tool; pharmacology ... See more keywords