Chemical and thermal sensitivity of medaka TRPA1 analyzed in heterologous expression system.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.057
Abstract: TRPA1 of insects and several tetrapod vertebrates except for those of rodents have been reported to be activated by noxious chemicals and also by high temperature with a relatively clear threshold. We previously analyzed the… read more here.
Keywords: trpa1; medaka; chemical thermal; heat ... See more keywords
TRPA1 is selected as a semi-conserved channel during vertebrate evolution due to its involvement in spermatogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.02.121
Abstract: TRPA1 is a non-selective cation channel originated in invertebrates. The genomic locus containing TRPA1 gene remains highly conserved and retained in all vertebrates. TRPA1 gene is evolutionarily selected, yet maintained as a highly diverged protein.… read more here.
Keywords: semi conserved; trpa1; selected semi; vertebrate evolution ... See more keywords
Enhanced Sensory Coding in Mouse Vibrissal and Visual Cortex through TRPA1.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107935
Abstract: Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel, broadly expressed throughout the body. Despite its expression in the mammalian brain, little is known about the contribution of TRPA1 to cortical function. Here,… read more here.
Keywords: enhanced sensory; trpa1; cortex; vibrissal ... See more keywords
The neuro-immune interaction in airway inflammation through TRPA1 expression in CD4+ T cells of asthmatic mice.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106696
Abstract: Asthma is an inflammatory disorder of the airways dominated by a Th2-type pattern. Recently, an emerging interest arises whether transient receptor potential ankyrin 1 (TRPA1) plays a potential role in the adaptive immune response. In… read more here.
Keywords: cd4 cells; trpa1; asthmatic mice; expression ... See more keywords
Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2019.11.023
Abstract: Transient receptor potential channel subfamily A member 1 (TRPA1) is a Ca2+-permeable cation channel that serves as one of the primary sensors of environmental irritants and noxious substances. Many TRPA1 agonists are electrophiles that are… read more here.
Keywords: insights electrophile; trpa1; structural insights; channel ... See more keywords
Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2016.08.028
Abstract: ABSTRACT Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke‐induced lung injury, we… read more here.
Keywords: high level; trpa1; level acrolein; mice ... See more keywords
A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38852-9
Abstract: Current medications inadequately treat the symptoms of chronic pain experienced by over 50 million people in the United States, and may come with substantial adverse effects signifying the need to find novel treatments. One novel… read more here.
Keywords: trpa1 mediated; trpa1; screening tool; pharmacology ... See more keywords
Transient receptor potential ankyrin 1 (TRPA1)-mediated toxicity: friend or foe?
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2019.1652872
Abstract: Abstract Transient receptor potential (TRP) channels have been widely studied during the last decade. New studies uncover new features and potential applications for these channels. TRPA1 has a huge distribution all over the human body… read more here.
Keywords: trpa1; receptor potential; toxicity; transient receptor ... See more keywords
Neuronal and non-neuronal TRPA1 as therapeutic targets for pain and headache relief
Sign Up to like & getrecommendations! Published in 2022 at "Temperature"
DOI: 10.1080/23328940.2022.2075218
Abstract: ABSTRACT The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of channels, has a major role in different types of pain. TRPA1 is primarily localized to a subpopulation of primary sensory… read more here.
Keywords: trpa1; neuronal non; pain headache; receptor ... See more keywords
TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac273
Abstract: Abstract Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced colorectal cancer, often leads to a form of chemotherapy-induced peripheral neuropathy characterized… read more here.
Keywords: trpa1; chemotherapy induced; peripheral neuropathy; sigma receptor ... See more keywords
Knockout of transient receptor potential ankyrin 1 (TRPA1) modulates the glial phenotype and alleviates perihematomal neuroinflammation after intracerebral hemorrhage in mice via MAPK/NF-κB signaling
Sign Up to like & getrecommendations! Published in 2022 at "Neuroreport"
DOI: 10.1097/wnr.0000000000001862
Abstract: The objective is to explore the role of astrocytic transient receptor potential ankyrin 1 (TRPA1) in glial phenotype transformation in neuroinflammation after intracerebral hemorrhage (ICH). Wild-type astrocytes and TRPA1−/− astrocytes were subjected to 6-h hemin… read more here.
Keywords: trpa1; ich mice; neuroinflammation; mice ... See more keywords