Development of an in vivo target-engagement biomarker for TRPA1 antagonists in humans.
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DOI: 10.1111/bcp.13143
Abstract: AIM To develop a non-invasive, safe and reproducible target-engagement biomarker for future TRPA1 antagonists in healthy volunteers. METHODS Dose finding (n = 11): 3%, 10%, and 30% cinnamaldehyde (CA) and placebo (= vehicle) was topically applied on… read more here.
Keywords: min; target engagement; engagement biomarker; trpa1 antagonists ... See more keywords