Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation
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DOI: 10.1038/s41598-018-30534-2
Abstract: Bacterial lipopolysaccharides (LPS) activate the TRPA1 cation channels in sensory neurons, leading to acute pain and inflammation in mice and to aversive behaviors in fruit flies. However, the precise mechanisms underlying this effect remain elusive.… read more here.
Keywords: lipid membranes; trpa1 mediated; activate trpa1; bacterial lipopolysaccharides ... See more keywords
A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38852-9
Abstract: Current medications inadequately treat the symptoms of chronic pain experienced by over 50 million people in the United States, and may come with substantial adverse effects signifying the need to find novel treatments. One novel… read more here.
Keywords: trpa1 mediated; trpa1; screening tool; pharmacology ... See more keywords