Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-57732-6_25
Abstract: TRPC channels have been suggested as potential candidates mediating store-operated Ca2+ entry (SOCE) in cardiomyocytes. There is increasing evidence that the TRPC isoforms TRPC1 and TRPC4 might fulfill the function as SOCs, in concert with… read more here.
Keywords: trpc channels; disease; trpc; pathology ... See more keywords
TRPC Channels and Brain Inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-94-024-1088-4_10
Abstract: Nonresolving low-grade inflammation is supposed to underly the basis of chronic disorders including cardiovascular diseases, cancer, diabetes, obesity, and psychiatric disorders such as depression and Alzheimer's diseases. There is increasing evidence suggesting that pathophysiology of… read more here.
Keywords: channels brain; trpc channels; psychiatric disorders; inflammation ... See more keywords
TRPC Channels and Mental Disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-94-024-1088-4_12
Abstract: Transient receptor potential canonical (TRPC) channels mediate the influx of different types of cations through the cell membrane and are involved in many functions of the organism. Evidences of involvement of TRPC channels in neuronal… read more here.
Keywords: trpc channels; trpc; biology; mental disorders ... See more keywords
TRPC Channel Structure and Properties.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-94-024-1088-4_2
Abstract: TRPC channels are the first identified members in the TRP family. They function as either homo- or heterotetramers regulating intracellular Ca2+ concentration in response to numerous physiological or pathological stimuli. TRPC channels are nonselective cation… read more here.
Keywords: trpc channels; structure properties; channel structure; biology ... See more keywords
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine.
Sign Up to like & getrecommendations! Published in 2021 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-030121-122314
Abstract: Transient receptor potential canonical (TRPC) proteins assemble to form homo- or heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC channels are thought to act as complex integrators of physical and chemical environmental… read more here.
Keywords: medicine; cardiovascular metabolic; trpc channels; pharmacology ... See more keywords
Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.618663
Abstract: The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2+]i) rise, which are not only important for regulating cell function but their deregulation… read more here.
Keywords: ischemic stroke; trpc channels; contribution; excitotoxicity ... See more keywords
Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2020.00070
Abstract: Stroke remains a leading cause of death, disability, and medical care burden worldwide. However, transformation from laboratory findings toward effective pharmacological interventions for clinical stroke has been unsatisfactory. Novel evidence has been gained on the… read more here.
Keywords: targets stroke; trpc channels; channels trpc6; trpc ... See more keywords
TRPC Channels in the Physiology and Pathophysiology of the Renal Tubular System: What Do We Know?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010181
Abstract: The study of transient receptor potential (TRP) channels has dramatically increased during the past few years. TRP channels function as sensors and effectors in the cellular adaptation to environmental changes. Here, we review literature investigating… read more here.
Keywords: trpc channels; tubular system; renal tubular; physiology ... See more keywords
Immunohistochemistry Reveals TRPC Channels in the Human Hearing Organ—A Novel CT-Guided Approach to the Cochlea
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119290
Abstract: TRPC channels are critical players in cochlear hair cells and sensory neurons, as demonstrated in animal experiments. However, evidence for TRPC expression in the human cochlea is still lacking. This reflects the logistic and practical… read more here.
Keywords: trpc channels; channels human; immunohistochemistry reveals; reveals trpc ... See more keywords