TRPC3 overexpression and intervention in airway smooth muscle of ovalbumin‐induced hyperresponsiveness and remodeling
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10970
Abstract: Transient receptor potential canonical channel 3 (TRPC3) proteins function as non‐voltage‐gated Ca2+‐permeable channels and play divergent roles in many processes of pathophysiology. The purpose of this study was to determine the relationship between TRPC3 expression… read more here.
Keywords: trpc3; hyperresponsiveness remodeling; smooth muscle; mice ... See more keywords
Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1290-7
Abstract: Williams syndrome (WS) and 7q11.23 duplication syndrome (Dup7q11.23) are neurodevelopmental disorders caused by the deletion and duplication, respectively, of ~ 25 protein-coding genes on chromosome 7q11.23. The general transcription factor 2I (GTF2I, protein TFII-I) is one… read more here.
Keywords: transcription factor; trpc3; calcium entry; factor regulates ... See more keywords
Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3.
Sign Up to like & getrecommendations! Published in 2018 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.12.025
Abstract: BACKGROUND AND AIMS Recent in vitro studies have showed that in macrophages, deletion of the non-selective Ca2+-permeable channel TRPC3 impairs expression of the osteogenic protein BMP-2. The pathophysiological relevance of this effect in atherosclerotic plaque calcification… read more here.
Keywords: ldlr mice; trpc3; mice macrophage; calcification ... See more keywords
A single point mutation in the TRPC3 lipid-recognition window generates supersensitivity to benzimidazole channel activators.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2019.02.007
Abstract: Mutation of a single residue within the recently identified lipid (diacylglycerol) recognition window of TRPC3 (G652A) was found to abolish channel activation via endogenous lipid mediators while retaining sensitivity to the non-lipid activator GSK1702934A (abb.… read more here.
Keywords: channel; trpc3; mutation; recognition window ... See more keywords
TRPC3, an underestimated, universal pacemaker channel?
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102484
Abstract: Transient receptor potential channel canonical 3 (TRPC3) is a cation channel with poor Ca2+ selectivity and significant constitutive activity. One of the channels' features is its striking ability to couple in a surprisingly versatile manner… read more here.
Keywords: trpc3; trpc3 underestimated; pacemaker channel; channel ... See more keywords
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14335
Abstract: Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation underlies many fundamental physiological processes. GPCR signalling is negatively regulated by β-arrestins, adaptor molecules that also activate different intracellular signalling pathways. Here we reveal that… read more here.
Keywords: trpc3; acute catecholamine; secretion; catecholamine secretion ... See more keywords
Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-57733-0
Abstract: Human status epilepticus (SE) is associated with a pathological reduction in cerebral blood flow termed the inverse hemodynamic response (IHR). Canonical transient receptor potential 3 (TRPC3) channels are integral to the propagation of seizures in… read more here.
Keywords: blood flow; trpc3; status epilepticus; smooth muscle ... See more keywords
Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep39867
Abstract: In previous studies using mice with macrophage-specific loss of TRPC3 we found a significant, selective effect of TRPC3 on the biology of M1, or inflammatory macrophages. Whereas activation of some components of the unfolded protein… read more here.
Keywords: trpc3; transcriptomic profiling; deep transcriptomic; biology ... See more keywords
Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13741
Abstract: Proximal tubular (PT) cells reabsorb most calcium (Ca2+), phosphate (PO43−), bicarbonate (HCO3−), and oxalate (C2O42−) ions. We have shown that mice lacking Transient Receptor Potential Canonical 3 (TRPC3−/−) channel are moderately hypercalciuric with presentation of… read more here.
Keywords: tubular cells; proximal tubular; cap; mice ... See more keywords
Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202154276
Abstract: Coordination of lipids within transient receptor potential canonical channels (TRPCs) is essential for their Ca2+ signaling function. Single particle cryo‐EM studies identified two lipid interaction sites, designated L1 and L2, which are proposed to accommodate… read more here.
Keywords: trpc3; channel state; dag; sensitized channel ... See more keywords
miR-199a Is Upregulated in GDM Targeting the MeCP2-Trpc3 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.917386
Abstract: Gestational diabetes mellitus (GDM), the most common medical pregnancy complication, has become a growing problem. More and more studies have shown that microRNAs are closely related to metabolic processes. The purpose of this paper is… read more here.
Keywords: gdm; upregulated gdm; mir 199a; trpc3 ... See more keywords