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Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10970
Abstract: Transient receptor potential canonical channel 3 (TRPC3) proteins function as non‐voltage‐gated Ca2+‐permeable channels and play divergent roles in many processes of pathophysiology. The purpose of this study was to determine the relationship between TRPC3 expression…
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Keywords:
trpc3;
hyperresponsiveness remodeling;
smooth muscle;
mice ... See more keywords
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Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1290-7
Abstract: Williams syndrome (WS) and 7q11.23 duplication syndrome (Dup7q11.23) are neurodevelopmental disorders caused by the deletion and duplication, respectively, of ~ 25 protein-coding genes on chromosome 7q11.23. The general transcription factor 2I (GTF2I, protein TFII-I) is one…
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Keywords:
transcription factor;
trpc3;
calcium entry;
factor regulates ... See more keywords
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Published in 2018 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.12.025
Abstract: BACKGROUND AND AIMS Recent in vitro studies have showed that in macrophages, deletion of the non-selective Ca2+-permeable channel TRPC3 impairs expression of the osteogenic protein BMP-2. The pathophysiological relevance of this effect in atherosclerotic plaque calcification…
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Keywords:
ldlr mice;
trpc3;
mice macrophage;
calcification ... See more keywords
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Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2019.02.007
Abstract: Mutation of a single residue within the recently identified lipid (diacylglycerol) recognition window of TRPC3 (G652A) was found to abolish channel activation via endogenous lipid mediators while retaining sensitivity to the non-lipid activator GSK1702934A (abb.…
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Keywords:
channel;
trpc3;
mutation;
recognition window ... See more keywords
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Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102484
Abstract: Transient receptor potential channel canonical 3 (TRPC3) is a cation channel with poor Ca2+ selectivity and significant constitutive activity. One of the channels' features is its striking ability to couple in a surprisingly versatile manner…
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Keywords:
trpc3;
trpc3 underestimated;
pacemaker channel;
channel ... See more keywords
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Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14335
Abstract: Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation underlies many fundamental physiological processes. GPCR signalling is negatively regulated by β-arrestins, adaptor molecules that also activate different intracellular signalling pathways. Here we reveal that…
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Keywords:
trpc3;
acute catecholamine;
secretion;
catecholamine secretion ... See more keywords
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Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-57733-0
Abstract: Human status epilepticus (SE) is associated with a pathological reduction in cerebral blood flow termed the inverse hemodynamic response (IHR). Canonical transient receptor potential 3 (TRPC3) channels are integral to the propagation of seizures in…
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Keywords:
blood flow;
trpc3;
status epilepticus;
smooth muscle ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep39867
Abstract: In previous studies using mice with macrophage-specific loss of TRPC3 we found a significant, selective effect of TRPC3 on the biology of M1, or inflammatory macrophages. Whereas activation of some components of the unfolded protein…
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Keywords:
trpc3;
transcriptomic profiling;
deep transcriptomic;
biology ... See more keywords
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Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13741
Abstract: Proximal tubular (PT) cells reabsorb most calcium (Ca2+), phosphate (PO43−), bicarbonate (HCO3−), and oxalate (C2O42−) ions. We have shown that mice lacking Transient Receptor Potential Canonical 3 (TRPC3−/−) channel are moderately hypercalciuric with presentation of…
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Keywords:
tubular cells;
proximal tubular;
cap;
mice ... See more keywords
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Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202154276
Abstract: Coordination of lipids within transient receptor potential canonical channels (TRPCs) is essential for their Ca2+ signaling function. Single particle cryo‐EM studies identified two lipid interaction sites, designated L1 and L2, which are proposed to accommodate…
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Keywords:
trpc3;
channel state;
dag;
sensitized channel ... See more keywords
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Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.917386
Abstract: Gestational diabetes mellitus (GDM), the most common medical pregnancy complication, has become a growing problem. More and more studies have shown that microRNAs are closely related to metabolic processes. The purpose of this paper is…
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Keywords:
gdm;
upregulated gdm;
mir 199a;
trpc3 ... See more keywords