Myoglobin-driven ET-1 production and downstream activation of TRPC3- but not TRPC6-dependent vasoconstriction contributes to rhabdomyolysis-induced AKI
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DOI: 10.1152/physiol.2023.38.s1.5732590
Abstract: Acute kidney injury (AKI) is the most severe and life-threatening complication of rhabdomyolysis, with 10-40% of patients developing some form of kidney insufficiency within days. Experimental evidence indicates that renal vasoconstriction plays a significant role… read more here.
Keywords: production; physiology; rhabdomyolysis induced; trpc3 trpc6 ... See more keywords