TRPC4/5 inhibitors: Phase I results and proof of concept studies
Sign Up to like & getrecommendations! Published in 2024 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-024-01890-0
Abstract: Transient receptor potential canonical (TRPC) ion channels are expressed in areas of the brain responsible for processing emotion and mood and have been implicated in the pathophysiology of internalizing disorders such as major depressive disorder… read more here.
Keywords: ion channels; inhibitors phase; trpc4 inhibitors; phase results ... See more keywords
Property-Based Design of Xanthine Derivatives as Potent and Orally Available TRPC4/5 Inhibitors for Depression and Anxiety.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02870
Abstract: Transient receptor potential canonical channels 4 and 5 (TRPC4/5) are nonselective cation channels involved in emotional regulation, positioning them to be promising targets for treating mental disorders such as anxiety and depression. HC-070, a potent… read more here.
Keywords: property based; trpc4 inhibitors; trpc4; based design ... See more keywords