TRPC4/5 inhibitors: Phase I results and proof of concept studies
Sign Up to like & getrecommendations! Published in 2024 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-024-01890-0
Abstract: Transient receptor potential canonical (TRPC) ion channels are expressed in areas of the brain responsible for processing emotion and mood and have been implicated in the pathophysiology of internalizing disorders such as major depressive disorder… read more here.
Keywords: ion channels; inhibitors phase; trpc4 inhibitors; phase results ... See more keywords
Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice
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DOI: 10.1371/journal.pone.0191225
Abstract: Background Forty million adults in the US suffer from anxiety disorders, making these the most common forms of mental illness. Transient receptor potential channel canonical subfamily (TRPC) members 4 and 5 are non-selective cation channels… read more here.
Keywords: treatment 070; trpc5; 070 potent; trpc4 trpc5 ... See more keywords