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   Articles with "trpc5" as a keyword



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Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium‐dependent contraction in mouse carotid arteries

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recommendations! Published in 2019 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2018.11.002

Abstract: &NA; Augmented endothelium‐dependent contractions (EDC) contributes to endothelial dysfunction and vascular disease progression. An early signal in EDC is cytosolic [Ca2+]i rise in endothelial cells, which stimulates the production of contractile prostanoids, leading to vascular… read more here.

Keywords: endothelium dependent; carotid arteries; trpc5; mouse carotid ... See more keywords
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TRPC5 mediates TMZ resistance in TMZ-resistant glioblastoma cells via NFATc3-P-gp pathway

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recommendations! Published in 2021 at "Translational Oncology"

DOI: 10.1016/j.tranon.2021.101214

Abstract: P-glycoprotein (P-gp) acts as a pump to transport cytotoxic drugs out of cells and is upregulated in cancer cells. Suppressing the expression of P-gp is an effective strategy to overcome multidrug resistance in cancer chemotherapy.… read more here.

Keywords: glioblastoma; tmz resistant; trpc5; tmz resistance ... See more keywords
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Neuroprotective Potential of HC070, a Potent TRPC5 Channel Inhibitor in Parkinson's Disease Models: A Behavioral and Mechanistic Study.

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recommendations! Published in 2022 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.2c00403

Abstract: Transient receptor potential canonical 5 (TRPC5) channels are predominantly expressed in the striatum and substantia nigra of the brain. These channels are permeable to calcium ions and are activated by oxidative stress. The physiological involvement… read more here.

Keywords: trpc5; trpc5 channels; parkinson disease; study ... See more keywords
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Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

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recommendations! Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0191225

Abstract: Background Forty million adults in the US suffer from anxiety disorders, making these the most common forms of mental illness. Transient receptor potential channel canonical subfamily (TRPC) members 4 and 5 are non-selective cation channels… read more here.

Keywords: treatment 070; trpc5; 070 potent; trpc4 trpc5 ... See more keywords
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TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models

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recommendations! Published in 2021 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2021.721865

Abstract: Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of kidney disease, but… read more here.

Keywords: puromycin aminonucleoside; protects podocytes; trpc5; inhibition ... See more keywords