Novel localizations of TRPC5 channels suggest novel and unexplored roles: A study in the chick embryo brain.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental neurobiology"
DOI: 10.1002/dneu.22857
Abstract: Mammalian TRPC5 channels are predominantly expressed in the brain, where they increase intracellular Ca2+ and induce depolarization. Because they augment presynaptic vesicle release, cause persistent neural activity, and show constitutive activity, TRPC5s could play a… read more here.
Keywords: novel localizations; embryo brain; trpc5 channels; brain ... See more keywords
Neuroprotective Potential of HC070, a Potent TRPC5 Channel Inhibitor in Parkinson's Disease Models: A Behavioral and Mechanistic Study.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00403
Abstract: Transient receptor potential canonical 5 (TRPC5) channels are predominantly expressed in the striatum and substantia nigra of the brain. These channels are permeable to calcium ions and are activated by oxidative stress. The physiological involvement… read more here.
Keywords: trpc5; trpc5 channels; parkinson disease; study ... See more keywords