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   Articles with "trpc6" as a keyword



Increased CaSR and TRPC6 pulmonary vascular expression in the nitrofen-induced model of congenital diaphragmatic hernia

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recommendations! Published in 2017 at "Pediatric Surgery International"

DOI: 10.1007/s00383-017-4191-3

Abstract: Aims and objectivesThe high morbidity and mortality rates in congenital diaphragmatic hernia (CDH) are attributed primarily to severe lung hypoplasia and/or persistent pulmonary hypertension (PPH). PPH in CDH is characterized by abnormal vascular remodeling with… read more here.

Keywords: congenital diaphragmatic; microscopy; expression; cdh ... See more keywords

Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells.

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recommendations! Published in 2021 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2021.108134

Abstract: Transient receptor potential channel 6 (TRPC6) is a receptor-operated Ca2+ channel that plays an important role in Ca2+ influx in the majority of non-excitable cells and influences calcium signalling and cellular responses. Therefore, the purpose… read more here.

Keywords: channel; transient receptor; role; trpc6 ... See more keywords

TRPC6 in diabetic kidney disease: good guy or bad guy?

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recommendations! Published in 2019 at "Kidney international"

DOI: 10.1016/j.kint.2018.10.027

Abstract: An association of altered activity of transient receptor potential cation channel C6 (TRPC6) with the development of various diabetic complications was previously reported. In this issue, Wang et al. tested the contribution of TRPC6 in type… read more here.

Keywords: trpc6 diabetic; diabetic kidney; trpc6; guy ... See more keywords

Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-04067-z

Abstract: The present study was conducted to determine if TRPC6 regulates glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs). GFR was assessed in conscious TRPC6 wild type and knockout mice, and… read more here.

Keywords: filtration rate; glomerular filtration; ca2; trpc6 ... See more keywords

Discovery of a novel piperazine derivative, cmp2: a selective TRPC6 activator suitable for treatment of synaptic deficiency in Alzheimer’s disease hippocampal neurons

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-73849-z

Abstract: Alzheimer disease (AD) is characterized by progressive loss of memory. Synaptic loss is now the best correlate of cognitive dysfunction in patients with Alzheimer’s disease. Thus, restoration or limitation of synapse loss is a promising… read more here.

Keywords: alzheimer disease; trpc6; cmp2; novel piperazine ... See more keywords

Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells

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recommendations! Published in 2022 at "Renal Failure"

DOI: 10.1080/0886022x.2022.2134796

Abstract: Abstract Purpose Glomerular mesangial cell (GMC) dysfunction plays a vital role in the pathogenesis of diabetic kidney disease (DKD). Transient receptor potential canonical 6 (TRPC6) has been demonstrated to be involved in the development of… read more here.

Keywords: glomerular mesangial; transient receptor; trpc6; expression ... See more keywords

Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1101/2022.02.01.478727

Abstract: Platelets enhance coagulation by exposing phosphatidylserine (PS) on their cell surface in response to strong agonist activation. Transient receptor potential channels, including TRPC6, have been implicated in the calcium influx central to this process. Here,… read more here.

Keywords: trpc6e896k e896k; exposure; trpc6; gain function ... See more keywords

Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1101/2022.02.11.479954

Abstract: Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans. Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6. In vitro… read more here.

Keywords: trpc6 mutation; injury; trpc6; gain function ... See more keywords

Improvement of platelet preservation by inhibition of TRPC6.

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recommendations! Published in 2023 at "Transfusion medicine"

DOI: 10.1111/tme.12955

Abstract: The preservation of platelets (PLTs) by room temperature (RT) oscillation limits their shelf life to between 4 and 7 days because of the decrease in PLT function. TRPC6 is a non‐selective mechanically sensitive cation channel that… read more here.

Keywords: platelet preservation; trpc6; improvement platelet; inhibition trpc6 ... See more keywords

Activation of urotensin II receptor induces podocyte injury via TRPC6-mediated endoplasmic reticulum stress

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5731204

Abstract: Podocytes are essential for the glomerular filtration barrier in the kidney. Podocyte injury can lead to chronic kidney disease (CKD). One of the leading causes of CKD is diabetes mellitus. Plasma urotensin II (UII) levels… read more here.

Keywords: stress; cultured podocytes; trpc6; podocyte injury ... See more keywords

TRPC6 deficiency attenuates cardiac mitochondrial dysfunction and HFpEF induced by chronic high-fat diet and inhibition of nitric oxide synthesis with L-NAME

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recommendations! Published in 2025 at "Physiology"

DOI: 10.1152/physiol.2025.40.s1.0916

Abstract: Objective: Transient receptor potential canonical channel type 6 (TRPC6), a non-selective cation channel that mediates Ca 2+ influx, is expressed in the heart. Overexpression of TRPC6 has been suggested to participate in pathological cardiac hypertrophy.… read more here.

Keywords: mice; name; trpc6; physiology ... See more keywords