Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke
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DOI: 10.3390/ijms22042074
Abstract: Ischemic stroke is one of the most disabling diseases and a leading cause of death globally. Despite advances in medical care, the global burden of stroke continues to grow, as no effective treatments to limit… read more here.
Keywords: novel mechanistic; ischemic stroke; neurovascular coupling; trpc6 channels ... See more keywords
Reorganization and Suppression of Store-Operated Calcium Entry in Podocytes of Type 2 Diabetic Rats
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DOI: 10.3390/ijms24087259
Abstract: Type 2 diabetes mellitus (DM2) is a widespread metabolic disorder that results in podocyte damage and diabetic nephropathy. Previous studies demonstrated that TRPC6 channels play a pivotal role in podocyte function and their dysregulation is… read more here.
Keywords: reorganization; entry; store depletion; store ... See more keywords
Evaluation of the presence of TRPC6 channels in human vessels: A pilot study using immunohistochemistry
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DOI: 10.3892/br.2022.1525
Abstract: The TRPC6 channel is permeable to calcium ions as well as other ions and plays an important role in the physiology and pathophysiology of vessels. Findings from animal and cell culture experiments have shown its… read more here.
Keywords: human vessels; using immunohistochemistry; trpc6; channels human ... See more keywords