Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells
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DOI: 10.1038/s41598-017-06350-5
Abstract: The up-regulation of transient receptor potential channel 6 (TRPC6) has been found to contribute to the proliferation of pulmonary artery smooth muscle cells (PASMCs), and inhibition of phosphodiesterase-5 (PDE5) has been shown to suppress TRPC6… read more here.
Keywords: pasmcs; trpc6 expression; inhibition; expression ... See more keywords
Sildenafil Prevents Podocyte Injury via PPAR-γ-Mediated TRPC6 Inhibition.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2015080885
Abstract: Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria. Sildenafil reduces TRPC6 expression and activity in nonrenal cell types, although the mechanism is unknown. Peroxisome… read more here.
Keywords: ppar; trpc6 expression; sildenafil; expression ... See more keywords