Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models
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DOI: 10.1101/2022.02.11.479954
Abstract: Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans. Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6. In vitro… read more here.
Keywords: trpc6 mutation; injury; trpc6; gain function ... See more keywords