Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11733-5
Abstract: The transient receptor potential melastatin 2 (TRPM2) channel plays a key role in redox sensation in many cell types. Channel activation requires binding of both ADP-ribose (ADPR) and Ca2+. The recently published TRPM2 structures from… read more here.
Keywords: structural transitions; trpm2 channel; adpr ca2; ca2 ... See more keywords
Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel
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DOI: 10.1038/s41598-020-63577-5
Abstract: Hypoxia (HYPX) induced-overload Ca 2+ entry results in increase of mitochondrial oxidative stress, inflammation and apoptosis in several neurons. Ca 2+ permeable TRPM2 channel was gated by ADP-ribose (ADPR) and reactive oxygen species (ROS), although… read more here.
Keywords: inflammation; trpm2 channel; hypx; trpm2 ... See more keywords
Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaw3639
Abstract: Uromodulin inhibits systemic oxidative stress via TRPM2. The oxidative hypothesis Elevated plasma concentration of the kidney-derived protein uromodulin (THP) has been associated with better kidney function and decreased mortality in patients with and without kidney… read more here.
Keywords: kidney; trpm2 channel; systemic oxidative; oxidative stress ... See more keywords
Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00581
Abstract: As an oxidative stress sensor, transient receptor potential melastatin 2 (TRPM2) channel is involved in many physiological and pathological processes including warmth sensing, ischemia injury, inflammatory diseases and diabetes. Intracellular calcium is critical for TRPM2… read more here.
Keywords: trpm2 channel; terminus trpm2; calcium; channel activation ... See more keywords