Extracellular Signal‐Regulated Protein Kinase, c‐Jun N‐Terminal Protein Kinase, and Calcineurin Regulate Transient Receptor Potential M3 (TRPM3) Induced Activation of AP‐1
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DOI: 10.1002/jcb.25904
Abstract: Stimulation of transient receptor potential M3 (TRPM3) cation channels with pregnenolone sulfate induces an influx of Ca2+ ions into the cells and a rise in the intracellular Ca2+ concentration, leading to the activation of the… read more here.
Keywords: stimulation; trpm3; activation; protein kinase ... See more keywords
Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels
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DOI: 10.1080/19336950.2016.1207026
Abstract: ABSTRACT Several compounds have been proposed to stimulate TRPM3 Ca2+ channels. We recently showed that stimulation of TRPM3 channels with pregnenolone sulfate activated the transcription factor AP-1, while other proposed TRPM3 ligands (nifedipine, D-erythro-sphingosine) exhibited… read more here.
Keywords: trpm3; transcription; cim0216; gene transcription ... See more keywords
Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients
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DOI: 10.1186/s10020-019-0083-4
Abstract: BackgroundChronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a complex multifactorial disorder of unknown cause having multi-system manifestations. Although the aetiology of CFS/ME remains elusive, immunological dysfunction and more particularly reduced cytotoxic activity in natural killer… read more here.
Keywords: trpm3; cfs; cfs patients; pregnenolone sulfate ... See more keywords
TRPM3 in the eye and in the nervous system – from new findings to novel mechanisms
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DOI: 10.1515/hsz-2021-0403
Abstract: Abstract The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3’s best understood function is its role as a peripheral noxious heat sensor in mice. However, the channel… read more here.
Keywords: trpm3; system new; trpm3 eye; new findings ... See more keywords
Sulfated Progesterone Metabolites That Enhance Insulin Secretion Via Trpm3 are Reduced in Serum From Women with Gestational Diabetes Mellitus.
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DOI: 10.2337/db21-0702
Abstract: Serum progesterone sulfates were evaluated in the etiology of gestational diabetes mellitus (GDM). Serum progesterone sulfates were measured using ultra-performance liquid chromatography-tandem mass spectrometry in four patient cohorts: 1) the Hyperglycemia and Adverse Pregnancy Outcomes… read more here.
Keywords: trpm3; diabetes mellitus; gestational diabetes; insulin secretion ... See more keywords