Extracellular Signal‐Regulated Protein Kinase, c‐Jun N‐Terminal Protein Kinase, and Calcineurin Regulate Transient Receptor Potential M3 (TRPM3) Induced Activation of AP‐1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25904
Abstract: Stimulation of transient receptor potential M3 (TRPM3) cation channels with pregnenolone sulfate induces an influx of Ca2+ ions into the cells and a rise in the intracellular Ca2+ concentration, leading to the activation of the… read more here.
Keywords: stimulation; trpm3; activation; protein kinase ... See more keywords
Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels
Sign Up to like & getrecommendations! Published in 2017 at "Channels"
DOI: 10.1080/19336950.2016.1207026
Abstract: ABSTRACT Several compounds have been proposed to stimulate TRPM3 Ca2+ channels. We recently showed that stimulation of TRPM3 channels with pregnenolone sulfate activated the transcription factor AP-1, while other proposed TRPM3 ligands (nifedipine, D-erythro-sphingosine) exhibited… read more here.
Keywords: trpm3; transcription; cim0216; gene transcription ... See more keywords
TRPM3-mediated inhibition of active Na-K transport by the ocular lens epithelium
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1171
Abstract: Purpose: The TRPM3 channel is selectively expressed in the lens epithelium, a monolayer at the anterior lens surface, but undetectable in fiber cells that make up the lens bulk. A point mutation in TRPM3 gene… read more here.
Keywords: transport; physiology; response; trpm3 ... See more keywords
Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients
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DOI: 10.1186/s10020-019-0083-4
Abstract: BackgroundChronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a complex multifactorial disorder of unknown cause having multi-system manifestations. Although the aetiology of CFS/ME remains elusive, immunological dysfunction and more particularly reduced cytotoxic activity in natural killer… read more here.
Keywords: trpm3; cfs; cfs patients; pregnenolone sulfate ... See more keywords
TRPM3 in the eye and in the nervous system – from new findings to novel mechanisms
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DOI: 10.1515/hsz-2021-0403
Abstract: Abstract The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3’s best understood function is its role as a peripheral noxious heat sensor in mice. However, the channel… read more here.
Keywords: trpm3; system new; trpm3 eye; new findings ... See more keywords
Sulfated Progesterone Metabolites That Enhance Insulin Secretion Via Trpm3 are Reduced in Serum From Women with Gestational Diabetes Mellitus.
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DOI: 10.2337/db21-0702
Abstract: Serum progesterone sulfates were evaluated in the etiology of gestational diabetes mellitus (GDM). Serum progesterone sulfates were measured using ultra-performance liquid chromatography-tandem mass spectrometry in four patient cohorts: 1) the Hyperglycemia and Adverse Pregnancy Outcomes… read more here.
Keywords: trpm3; diabetes mellitus; gestational diabetes; insulin secretion ... See more keywords
Case Report: Expanded delineation of phenotype of TRPM3-related neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2024.1435053
Abstract: The TRPM3 gene, part of the transient receptor potential (TRP) cation channel family, plays crucial roles in sensory perception and ion transport. Mutations in TRPM3 are linked to a range of neurological and developmental disorders.… read more here.
Keywords: neurodevelopmental disorders; trpm3 related; related neurodevelopmental; case ... See more keywords