Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels
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DOI: 10.1080/19336950.2016.1207026
Abstract: ABSTRACT Several compounds have been proposed to stimulate TRPM3 Ca2+ channels. We recently showed that stimulation of TRPM3 channels with pregnenolone sulfate activated the transcription factor AP-1, while other proposed TRPM3 ligands (nifedipine, D-erythro-sphingosine) exhibited… read more here.
Keywords: trpm3; transcription; cim0216; gene transcription ... See more keywords
Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1
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DOI: 10.3390/ijms222313133
Abstract: In pancreatic β-cells of the line INS-1, glucose uptake and metabolism induce the openings of Ca2+-permeable TRPM3 channels that contribute to the elevation of the intracellular Ca2+ concentration and the fusion of insulin granules with… read more here.
Keywords: cells line; pancreatic cells; phosphorylation; trpm3 channels ... See more keywords