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   Articles with "trpm4" as a keyword



Involvement of TRPM4 in detrusor overactivity following spinal cord transection in mice

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recommendations! Published in 2018 at "Naunyn-Schmiedeberg's Archives of Pharmacology"

DOI: 10.1007/s00210-018-1542-0

Abstract: Transient receptor potential cation channel subfamily M member 4 (TRPM4) has been shown to play a key role in detrusor contractility under physiological conditions. In this study, we investigated the potential role of TRPM4 in… read more here.

Keywords: following spinal; detrusor; trpm4; detrusor overactivity ... See more keywords
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Genetic background influences expression and function of the cation channel TRPM4 in the mouse heart

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recommendations! Published in 2020 at "Basic Research in Cardiology"

DOI: 10.1007/s00395-020-00831-x

Abstract: Transient receptor potential melastatin 4 (TRPM4) cation channels act in cardiomyocytes as a negative modulator of the L-type Ca2+ current. Ubiquitous Trpm4 deletion in mice leads to an increased β-adrenergic inotropy in healthy mice as… read more here.

Keywords: cation; trpm4; genetic background; background ... See more keywords

Serum SUR1 and TRPM4 in patients with subarachnoid hemorrhage

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recommendations! Published in 2019 at "Neurosurgical Review"

DOI: 10.1007/s10143-019-01200-6

Abstract: Neuroinflammation plays an important role in neuronal injury after aneurysmal subarachnoid hemorrhage (aSAH). Sulfonylurea receptor 1 (SUR1) and transient receptor potential cation channel subfamily M member 4 (TRPM4) receptors play an important role in the… read more here.

Keywords: trpm4 levels; serum sur1; sur1 trpm4; trpm4 ... See more keywords

The TRPM4 channel is functionally important for the beneficial cardiac remodeling induced by endurance training

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recommendations! Published in 2017 at "Journal of Muscle Research and Cell Motility"

DOI: 10.1007/s10974-017-9466-8

Abstract: Cardiac hypertrophy (CH) is an adaptive process that exists in two distinct forms and allows the heart to adequately respond to an organism’s needs. The first form of CH is physiological, adaptive and reversible. The… read more here.

Keywords: trpm4 mice; trpm4 channel; endurance training; trpm4 ... See more keywords
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Small molecular inhibitors block TRPM4 currents in prostate cancer cells, with limited impact on cancer hallmarks functions.

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recommendations! Published in 2020 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2020.09.024

Abstract: Transient receptor potential melastatin 4 (TRPM4) is a broadly expressed Ca2+ activated monovalent cation channel that contributes to the pathophysiology of several diseases. For this study, we generated stable CRISPR/Cas9 TRPM4 knockout (K.O.) cells from… read more here.

Keywords: trpm4; block trpm4; prostate cancer; cancer cells ... See more keywords

Structures of the Calcium-activated Non-Selective Cation Channel TRPM4

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recommendations! Published in 2017 at "Nature"

DOI: 10.1038/nature24997

Abstract: TRPM4 is a calcium-activated, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) -modulated, non-selective cation channel that belongs to the family of melastatin-related transient receptor potential (TRPM) channels. Here we present the electron cryo-microscopy structures of the mouse TRPM4 channel with… read more here.

Keywords: trpm4; cation channel; channel; non selective ... See more keywords

Identification of a binding site for small molecule inhibitors targeting human TRPM4

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-56131-2

Abstract: Transient receptor potential (TRP) melastatin 4 (TRPM4) protein is a calcium-activated monovalent cation channel associated with various genetic and cardiovascular disorders. The anthranilic acid derivative NBA is a potent and specific TRPM4 inhibitor, but its… read more here.

Keywords: binding site; site small; human trpm4; trpm4 ... See more keywords

Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion

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recommendations! Published in 2019 at "Journal of Neurotrauma"

DOI: 10.1089/neu.2018.5986

Abstract: Abstract In severe traumatic brain injury (TBI), contusions often are worsened by contusion expansion or hemorrhagic progression of contusion (HPC), which may double the original contusion volume and worsen outcome. In humans and rodents with… read more here.

Keywords: trpm4; contusion; kir6; sur1 trpm4 ... See more keywords

TRPM4 drives cerebral edema by switching to alternative splicing isoform after experimental traumatic brain injury.

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recommendations! Published in 2023 at "Journal of neurotrauma"

DOI: 10.1089/neu.2022.0503

Abstract: Traumatic brain injury (TBI) affects people of all ages and is recognized as a major cause of death and disability worldwide, also brings heavy life burden to patients and their families. However, the treatment of… read more here.

Keywords: trpm4; brain; cerebral edema; alternative splicing ... See more keywords

TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias.

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recommendations! Published in 2022 at "European heart journal"

DOI: 10.1093/eurheartj/ehac354

Abstract: AIMS Cardiac arrhythmias are a major factor in the occurrence of morbidity and sudden death in patients with cardiovascular disease. Disturbances of Ca2+ homeostasis in the heart contribute to the initiation and maintenance of cardiac… read more here.

Keywords: arrhythmias trpm4; trpm4; dependent triggered; ca2 dependent ... See more keywords

Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis

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recommendations! Published in 2017 at "Journal of Neuroinflammation"

DOI: 10.1186/s12974-017-0953-z

Abstract: BackgroundIn multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), inflammation is perpetuated by both infiltrating leukocytes and astrocytes. Recent work implicated SUR1-TRPM4 channels, expressed mostly by astrocytes, in murine EAE. We tested the hypothesis that… read more here.

Keywords: trpm4; chronic phase; autoimmune encephalomyelitis; sur1 trpm4 ... See more keywords